Treatment Strategy to Enhance Nrf2 Signaling in Older Adults

Description

Exercise is the cornerstone of disease prevention and often an important component of treatment. However, the efficacy of an exercise stimulus is reduced with aging. This study will investigate whether adding a treatment with phytonutrients found in cruciferous vegetables can improve the exercise response in older individuals.

Conditions

Aging Problems

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Study Overview

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Study Details

Study overview

Exercise is the cornerstone of disease prevention and often an important component of treatment. However, the efficacy of an exercise stimulus is reduced with aging. This study will investigate whether adding a treatment with phytonutrients found in cruciferous vegetables can improve the exercise response in older individuals.

Treatment Strategy to Enhance Nrf2 Signaling in Older Adults: Combining Acute Exercise With the Phytochemical Sulforaphane

Treatment Strategy to Enhance Nrf2 Signaling in Older Adults

Condition
Aging Problems
Intervention / Treatment

-

Contacts and Locations

Flagstaff

Northern Arizona University, Flagstaff, Arizona, United States, 86011

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Men and women, 60 years and older
  • * Competent to independently give informed consent
  • * Successful completion of screening
  • * Maximal oxygen consumption below the 60th percentile based on gender:
  • * Women: ≤ 21.2 mL/kg/min
  • * Men: ≤ 30.5 mL/kg/min
  • * Estrogen supplementation (in any form) within the previous 6 months
  • * Any medication that could affect outcome measures such as statins, blood pressure medications, or anti-depressives
  • * Use of anti-oxidant supplements, in excess of standard multi-vitamins (1 tablet/day) and/or any supplements known to target Nrf2 including resveratrol, Protandim, and sulforaphane
  • * Current smoker
  • * Body Mass Index (BMI) greater than 33 kg/m2 (Class I Obesity)
  • * Any chronic illness that could affect outcome measures, including diabetes, liver or renal disease, or cancer (other than skin cancer)
  • * History of a myocardial infarction within the last 6 months, clinically significant aortic stenosis, use of cardiac defibrillator, or uncontrolled angina
  • * Clinically significant arrhythmia on a resting EKG or significant EKG changes during the baseline VO2 max test
  • * Any other condition that would contraindicate maximal exercise testing, including elevated blood pressure at rest (systolic BP \>150 or diastolic BP \>90 mm Hg on at least 2 measurements, at least 10 minutes apart) or musculoskeletal problems

Ages Eligible for Study

60 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Northern Arizona University,

Study Record Dates

2025-05-31