COMPLETED

Blood Flow Regulation in Individuals With Down Syndrome - Training Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Work capacity is an important predictor of declining health or physical function, and of mortality, and is commonly measured as peak oxygen consumption. Peak oxygen consumption is very low in individuals with Down syndrome, the most prevalent genetic cause of intellectual disability. Previous research suggests individuals with Down syndrome may experience a double disadvantage when they are exercising: they may not be able to increase cardiac output sufficiently and they may not be able to allocate adequate blood flow to the working muscles. The aim of this research proposal is therefore to investigate the responses in central and peripheral blood flow regulation and cardiac autonomic function to exercise training in individuals with DS. Additionally the effects of exercise on gait, balance and attitude towards exercise in individuals with DS are investigated.

Official Title

The Effects of Exercise Training on Central and Peripheral Blood Flow Regulation in Individuals With Down Syndrome

Quick Facts

Study Start:2021-09-09
Study Completion:2024-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT04854122

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 35 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * generally healthy
  2. * sedentary (defined as being involved in less than 30 minutes of moderately-intense physical activity per day)
  3. * additionally for the participants with Down syndrome:
  4. * diagnosis of Down syndrome trisomy 21 and
  5. * normal thyroid function or stable thyroid function (and medications) for at least 6 mo.
  1. * congenital heart disease;
  2. * atherosclerotic or other vascular disease;
  3. * asthma or other pulmonary disease;
  4. * hypertension (defined BP \>140/90 mmHg);
  5. * blood pressure below 90/60 mmHg;
  6. * history of pre-syncope or syncope;
  7. * diabetes (defined as Hba1c of \>7.5% or use of glucose lowering medication);
  8. * severe obesity (defined as BMI \>40);
  9. * medications affecting heart rate, blood pressure or arterial function;
  10. * anti-inflammatory medication including NSAIDS;
  11. * current smoking and
  12. * pregnancy.

Contacts and Locations

Principal Investigator

Thessa Hilgenkamp, PhD
PRINCIPAL_INVESTIGATOR
University of Nevada, Las Vegas

Study Locations (Sites)

University of Nevada, Las Vegas
Las Vegas, Nevada, 89154
United States

Collaborators and Investigators

Sponsor: University of Nevada, Las Vegas

  • Thessa Hilgenkamp, PhD, PRINCIPAL_INVESTIGATOR, University of Nevada, Las Vegas

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-09-09
Study Completion Date2024-08-31

Study Record Updates

Study Start Date2021-09-09
Study Completion Date2024-08-31

Terms related to this study

Keywords Provided by Researchers

  • exercise
  • blood flow regulation
  • blood pressure
  • heart rate

Additional Relevant MeSH Terms

  • Down Syndrome