Blood Flow Regulation in Individuals With Down Syndrome - Training Study

Description

Work capacity is an important predictor of declining health or physical function, and of mortality, and is commonly measured as peak oxygen consumption. Peak oxygen consumption is very low in individuals with Down syndrome, the most prevalent genetic cause of intellectual disability. Previous research suggests individuals with Down syndrome may experience a double disadvantage when they are exercising: they may not be able to increase cardiac output sufficiently and they may not be able to allocate adequate blood flow to the working muscles. The aim of this research proposal is therefore to investigate the responses in central and peripheral blood flow regulation and cardiac autonomic function to exercise training in individuals with DS. Additionally the effects of exercise on gait, balance and attitude towards exercise in individuals with DS are investigated.

Conditions

Down Syndrome

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Study Overview

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Study Details

Study overview

Work capacity is an important predictor of declining health or physical function, and of mortality, and is commonly measured as peak oxygen consumption. Peak oxygen consumption is very low in individuals with Down syndrome, the most prevalent genetic cause of intellectual disability. Previous research suggests individuals with Down syndrome may experience a double disadvantage when they are exercising: they may not be able to increase cardiac output sufficiently and they may not be able to allocate adequate blood flow to the working muscles. The aim of this research proposal is therefore to investigate the responses in central and peripheral blood flow regulation and cardiac autonomic function to exercise training in individuals with DS. Additionally the effects of exercise on gait, balance and attitude towards exercise in individuals with DS are investigated.

The Effects of Exercise Training on Central and Peripheral Blood Flow Regulation in Individuals With Down Syndrome

Blood Flow Regulation in Individuals With Down Syndrome - Training Study

Condition
Down Syndrome
Intervention / Treatment

-

Contacts and Locations

Las Vegas

University of Nevada, Las Vegas, Las Vegas, Nevada, United States, 89154

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * generally healthy
  • * sedentary (defined as being involved in less than 30 minutes of moderately-intense physical activity per day)
  • * additionally for the participants with Down syndrome:
  • * diagnosis of Down syndrome trisomy 21 and
  • * normal thyroid function or stable thyroid function (and medications) for at least 6 mo.
  • * congenital heart disease;
  • * atherosclerotic or other vascular disease;
  • * asthma or other pulmonary disease;
  • * hypertension (defined BP \>140/90 mmHg);
  • * blood pressure below 90/60 mmHg;
  • * history of pre-syncope or syncope;
  • * diabetes (defined as Hba1c of \>7.5% or use of glucose lowering medication);
  • * severe obesity (defined as BMI \>40);
  • * medications affecting heart rate, blood pressure or arterial function;
  • * anti-inflammatory medication including NSAIDS;
  • * current smoking and
  • * pregnancy.

Ages Eligible for Study

18 Years to 35 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Nevada, Las Vegas,

Thessa Hilgenkamp, PhD, PRINCIPAL_INVESTIGATOR, University of Nevada, Las Vegas

Study Record Dates

2024-08