Optimizing and Standardizing 129Xe Gas Exchange MRI to Visualize Regional Therapy Response in Interstitial Lung Disease

Description

The purpose of this multi-centered, NIH-sponsored study is to to develop an optimal protocol for using noninvasive 129Xe gas exchange MRI to detect changing disease activity in interstitial lung diseases (ILDs).

Conditions

Interstitial Lung Diseases

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Study Overview

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Study Details

Study overview

The purpose of this multi-centered, NIH-sponsored study is to to develop an optimal protocol for using noninvasive 129Xe gas exchange MRI to detect changing disease activity in interstitial lung diseases (ILDs).

Optimizing and Standardizing 129Xe Gas Exchange MRI to Visualize Regional Therapy Response in Interstitial Lung Disease

Optimizing and Standardizing 129Xe Gas Exchange MRI to Visualize Regional Therapy Response in Interstitial Lung Disease

Condition
Interstitial Lung Diseases
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa, Iowa City, Iowa, United States, 52242

Durham

Duke University Medical Center, Durham, North Carolina, United States, 27710

Cincinnati

University of Cincinnati, Cincinnati, Ohio, United States, 45219

Cincinnati

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States, 45229

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Outpatients of either gender, age greater than or equal to 18 years
  • 2. Willing and able to give informed consent and adhere to visit/protocol schedules (Consent must be given before any study procedures are performed.)
  • 3. Subject has no diagnosed pulmonary conditions
  • 4. Subject has not smoked in the previous 5 years
  • 5. Smoking history, if any, is less than or equal to 5 pack-years
  • 6. No history of using other inhaled products more than 1 time per week for \> 1 year
  • 1. Subject is less than 18 years old
  • 2. MRI is contraindicated based on responses to MRI screening questionnaire
  • 3. Subject is pregnant or lactating
  • 4. Resting oxygen saturation on room air \<90%
  • 5. Respiratory illness of a bacterial or viral etiology within 30 days of MRI
  • 6. Subject has history of any known ventricular cardiac arrhythmia
  • 7. Subject has history of cardiac arrest within the last year
  • 8. Subject does not fit into Xe vest coil used for MRI 129
  • 9. Subject cannot hold his/her breath for 15 seconds
  • 10. Subject deemed unlikely to be able to comply with instructions during imaging
  • 11. Medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Bastiaan Driehuys,

Joseph Mammarappallil, MD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

2025-03-31