AnalgeSiC and appEtite-stimulating Effects of caNnabigerol and THC (ASCENT)

Eligibility Criteria

• * Male or non-pregnant and non-lactating females aged 21-55 years
• * • Report occasional use of cannabis (cannabis use between ≥ biweekly and ≤ 3 days per week) over the month prior to screening
• * Not currently seeking treatment for their cannabis use
• * Have a Body Mass Index from 18.5 - 34kg/m2.
• * Able to perform all study procedures
• * Must be using a contraceptive (hormonal or barrier methods)
• * Females must not be lactating
• * Meeting DSM-V criteria for moderate-severe Cannabis Use disorder (CUD) or any substance use disorder other than nicotine, caffeine, or mild CUD
• * Any other Axis I disorder
• * • Current use of any medications within 14 days or 5 half-lives of administration (whichever is longer) except for hormonal contraceptives in females. If a medication is taken once a participant is enrolled, sessions will be suspended for 14 days or 5 half-lives after administration (whichever is longer)
• * If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process are not within the normal range and / or reveal any significant illness (e.g., hypertension) as judged by the study physician and to put the participant at greater risk of experiencing adverse events due to completion of study procedures.
• * Current pain
• * Pregnancy is exclusionary due to the possible effects of the study medication on fetal development.
• * History of an allergic reaction or adverse reaction to cannabis is exclusionary.
• * History of respiratory illness or current respiratory illness
• * Currently enrolled in another research protocol
• * Not using a contraceptive method (hormonal or barrier methods)
• * Insensitivity to the cold water stimulus of the Cold Pressor Test
• * Any disorders that might make cannabis administration hazardous are exclusionary, as determined by the evaluating physician