Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)

Description

The goal of the proposed research is to investigate Magnetic Resonance (MR) Fingerprinting and P-MRS (Phosphorus-31 MR Spectroscopy) imaging for characterization of skeletal muscle in heart failure patients with sarcopenia. Heart failure patients with and without sarcopenia will be scanned using MR Fingerprinting and an existing Post-exercise phosphocreatine (PCr) recovery MR imaging protocol to obtain characteristic profiles of quantitative T1, T2, and PCr recovery rate.

Conditions

Sarcopenia

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Study Overview

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Study Details

Study overview

The goal of the proposed research is to investigate Magnetic Resonance (MR) Fingerprinting and P-MRS (Phosphorus-31 MR Spectroscopy) imaging for characterization of skeletal muscle in heart failure patients with sarcopenia. Heart failure patients with and without sarcopenia will be scanned using MR Fingerprinting and an existing Post-exercise phosphocreatine (PCr) recovery MR imaging protocol to obtain characteristic profiles of quantitative T1, T2, and PCr recovery rate.

Sarcopenia Characterization Using Magnetic Resonance Fingerprinting and Phosphorous Magnetic Resonance Spectroscopic Imaging Evaluation (SUSIE)

Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)

Condition
Sarcopenia
Intervention / Treatment

-

Contacts and Locations

Cleveland

Cleveland Clinic, Cleveland, Ohio, United States, 44195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Heart failure patients
  • * Age ≥40 yrs
  • * Stable chronic heart failure
  • * Systolic dysfunction determined by cardiac MRI with left ventricle ejection fraction 40% or less
  • * Healthy Volunteers
  • * Age ≥40 yrs
  • * No diagnosed heart failure or sarcopenia
  • * Heart failure patients
  • * Healthy volunteers (controls)
  • * Advanced liver disease, advanced cancer, advanced chronic obstructive pulmonary disease
  • * Contraindications to MRI Contraindications to MRI
  • * Heart pacemaker/defibrillator
  • * Electronic/implanted stimulators or devices, including deep brain stimulator, vagus nerve stimulator, bladder stimulator, spine stimulator, neurostimulators; implanted electrodes or wires
  • * Cochlear implant or other ear implants
  • * Implanted drug pumps (insulin, narcotic/pain medications, drugs to treat spasticity)
  • * Programmable shunt
  • * Aneurysm clips and coils
  • * Stents
  • * Filters (for example, blood clot filters)
  • * Metal fragment in body or eye (eg, BBs, bullets, shrapnel, metal pieces or shavings)

Ages Eligible for Study

40 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

The Cleveland Clinic,

W. H. Wilson Tang, MD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Study Record Dates

2026-04-30