Do Endotypes Predict Response and Sequelae in OSA Patients

Description

This study will investigate why some people have Obstructive Sleep Apnea (OSA) and how the underlying cause may relate to OSA manifestations (including sleepiness and high blood pressure) and response to different therapeutic approaches (ie CPAP, eszopiclone, and supplemental oxygen). Understanding why someone has OSA could affect how best to treat that individual, but may also have an impact on what problems the disease might cause.

Conditions

Obstructive Sleep Apnea, Sleep Apnea, Sleep Apnea, Obstructive, Sleep, Sleep Disorder

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Study Overview

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Study Details

Study overview

This study will investigate why some people have Obstructive Sleep Apnea (OSA) and how the underlying cause may relate to OSA manifestations (including sleepiness and high blood pressure) and response to different therapeutic approaches (ie CPAP, eszopiclone, and supplemental oxygen). Understanding why someone has OSA could affect how best to treat that individual, but may also have an impact on what problems the disease might cause.

Do Endotypes Predict Response and Sequelae in OSA Patients

Do Endotypes Predict Response and Sequelae in OSA Patients

Condition
Obstructive Sleep Apnea
Intervention / Treatment

-

Contacts and Locations

La Jolla

Altman Clinical and Translational Research Institute Building, La Jolla, California, United States, 92037

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 21-65 years old
  • * Men and women with a physician diagnosis of OSA (or strongly suspected to have sleep apnea - \* see below)
  • * BMI 20 - 35 kg/m2
  • * Pregnancy (current or planned)
  • * Nursing
  • * Inability to provide self-consent or complete study procedures, such as questionnaires that are only available/validated in English.
  • * Already on effective therapy and adherent to treatment for OSA
  • * Other known untreated sleep fragmenting disorder, such as periodic limb movement disorder, or narcolepsy
  • * Circadian rhythm disorder
  • * Unrevascularized coronary artery disease, angina, prior heart attack or stroke, congestive heart failure
  • * Uncontrolled hypertension (systolic blood pressure \>160, diastolic blood pressure \>95)
  • * Chronic lung disease requiring the use of supplemental oxygen, or with evidence of hypercapnia due to obstructive lung disease.
  • * Presence of tracheostomy
  • * Hospitalization within the past 90 days
  • * Prior peptic ulcer disease, esophageal varices, or gastrointestinal bleeding (\< 5 years)
  • * Prior gastric bypass surgery
  • * Chronic liver disease or end-stage kidney disease
  • * Active cancer
  • * Allergy to any of the study drug
  • * Regular use of medications known to affect control of breathing (opioids, sedatives/hypnotics including benzodiazepines, theophylline)
  • * Chronically using study drug (Eszopiclone)
  • * Active illicit substance use
  • * Alcohol use of \>1 standard drink/night for women or \>2 standard drinks/night for men nightly alcohol use
  • * Active smoking or vaping within the past 6 months
  • * Psychiatric disease, other than controlled depression/anxiety
  • * Prisoners
  • * Subjects who are strongly suspected to have sleep apnea will be offered an overnight home sleep apnea test (HSAT) to verify OSA diagnosis.

Ages Eligible for Study

21 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Diego,

Atul Malhotra, MD, PRINCIPAL_INVESTIGATOR, Professor, Medicine

Christopher Schmickl, PRINCIPAL_INVESTIGATOR, Postdoc Fellow, Medicine

Study Record Dates

2027-01-01