RECRUITING

Prospective Evaluation of Topical Almond Oil vs Hydroquinone

Conditions

Quick Navigation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to analyze facial pigmentation and skin microbiome changes after topical almond oil application, compared to the use of topical hydroquinone.

Official Title

Prospective Evaluation of Topical Almond Oil vs Hydroquinone on the Appearance of Facial Pigmentation and the Stability of the Microbiome

Quick Facts

Study Start:2021-07-01

Study Completion:2026-08-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT04875715

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:FEMALE

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Premenopausal women of Fitzpatrick skin types 3 to 6	* Those with a nut allergy * Smoking is an independent risk factor and serves as a confounder for the development of facial aging \[18\]. Therefore current smokers, those that have smoked within the past year, and former smokers with greater than a 20 pack year history of smoking will be excluded. * Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndrome) will be excluded as this can be a confounder for facial photoaging. * Hormonal medications or therapies will not be allowed unless they have been stable on their medications for at least 2 months. Examples include oral contraceptives, progesterone-based injections, and estrogen based hormonal replacement therapy. * Those who have undergone any cosmetic procedures to the face in the 4 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment will also not be eligible. * Individuals who are unwilling to discontinue vitamin E containing supplements and food sources during the washout and intervention. * Individual who are unwilling to discontinue topical cosmetic products during the duration of the study. * Individuals who are not willing to engage in a two-week washout on topical treatments known to affect facial pigmentation and these agents will be restricted during the study period as well. These include topicals that contain: * Retinoids such as tretinoin, adapalene, retinol. * Antioxidant ingredients such as vitamin C or vitamin E. * Pigment-reducing agents such as hydroquinone, azelaic acid, kojic acid per the discretion of the investigator except for the hydroquinone that is provided in this study. * Topicals that contain a nut oil or nut extract as part of their ingredient list. * Furthermore, subjects will be asked to refrain from use of any other topical products for one week prior to each visit apart from the study agents supplied from this study.

Inclusion Criteria

Exclusion Criteria

* Premenopausal women of Fitzpatrick skin types 3 to 6

* Those with a nut allergy
* Smoking is an independent risk factor and serves as a confounder for the development of facial aging \[18\]. Therefore current smokers, those that have smoked within the past year, and former smokers with greater than a 20 pack year history of smoking will be excluded.
* Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndrome) will be excluded as this can be a confounder for facial photoaging.
* Hormonal medications or therapies will not be allowed unless they have been stable on their medications for at least 2 months. Examples include oral contraceptives, progesterone-based injections, and estrogen based hormonal replacement therapy.
* Those who have undergone any cosmetic procedures to the face in the 4 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment will also not be eligible.
* Individuals who are unwilling to discontinue vitamin E containing supplements and food sources during the washout and intervention.
* Individual who are unwilling to discontinue topical cosmetic products during the duration of the study.
* Individuals who are not willing to engage in a two-week washout on topical treatments known to affect facial pigmentation and these agents will be restricted during the study period as well. These include topicals that contain:
* Retinoids such as tretinoin, adapalene, retinol.
* Antioxidant ingredients such as vitamin C or vitamin E.
* Pigment-reducing agents such as hydroquinone, azelaic acid, kojic acid per the discretion of the investigator except for the hydroquinone that is provided in this study.
* Topicals that contain a nut oil or nut extract as part of their ingredient list.
* Furthermore, subjects will be asked to refrain from use of any other topical products for one week prior to each visit apart from the study agents supplied from this study.

Contacts and Locations

Study Contact

Iryna Rybak

CONTACT

916-551-2636

irybak@ucdavis.edu

Alexis Carrington

CONTACT

aecarrington@ucdavis.edu

Principal Investigator

Raja Sivamani, MD MS AP

PRINCIPAL_INVESTIGATOR

UC Davis Dermatology

Study Locations (Sites)

UC Davis Department of Dermatology, Clinical Trials Unit

Sacramento, California, 95816

United States

Collaborators and Investigators

Sponsor: University of California, Davis

Raja Sivamani, MD MS AP, PRINCIPAL_INVESTIGATOR, UC Davis Dermatology

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-07-01

Study Completion Date2026-08-01

Study Record Updates

Study Start Date2021-07-01

Study Completion Date2026-08-01

Terms related to this study

Additional Relevant MeSH Terms

Skin Pigmentation