Detection of Barrett s Esophagus in Patients Without GERD Symptoms

Description

The purpose of this study is to develop a method to detect Barrett's esophagus (BE) in individuals with a new office-based diagnostic test.

Conditions

Barrett's Esophagus

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Study Overview

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Study Details

Study overview

The purpose of this study is to develop a method to detect Barrett's esophagus (BE) in individuals with a new office-based diagnostic test.

Detection of Barrett s Esophagus in Patients Without Gastroesophageal Reflux Disease (GERD) Symptoms

Detection of Barrett s Esophagus in Patients Without GERD Symptoms

Condition
Barrett's Esophagus
Intervention / Treatment

-

Contacts and Locations

Cleveland

University Hospitals Cleveland Medical Center, Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States, 44106-5065

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * No known coagulopathy, no known esophageal varices.
  • * No significant dysphagia or odynophagia
  • * Absence of chronic GERD, defined as five or more years of heartburn or regurgitation with symptoms at least once a week when not on medications for GERD symptoms.
  • * Subjects to qualify must meet criterion 3, be over age 50, and have two additional risk factors for BE (white race, central obesity defined as waist size \>35 inches for women and \>40 inches for men, male gender, current smoker or smoking history \>10 pack years, confirmed family history in at least two members with one being a first degree relative).
  • * History of prior EGD procedure
  • * Inability to provide written informed consent
  • * History of weekly of more frequent heartburn or regurgitation for five or more years
  • * On anti-coagulant drug(s)that cannot be temporarily discontinued or coagulopathy with international normalized ratio (INR) \> 1.5
  • * Known history of esophageal varices or esophageal stricture
  • * Any contraindication, as deemed inInvestigator's medical judgment, to undergoing the EsoCheck procedure, undergoing the EGDprocedure,and/or having biopsies taken, including but not limited to due to comorbidities such as coagulopathy or a known history of esophageal diverticula, esophageal fistula and/or esophageal ulceration
  • * History of difficulty swallowing (dysphagia) or painful swallowing (odynophagia), including swallowing pills
  • * Oropharyngeal tumor
  • * History of esophageal or gastric surgery, with exception on uncomplicated surgical fundoplication procedure
  • * History of myocardial infarction or cerebrovascular accident within past 6 months

Ages Eligible for Study

50 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Case Comprehensive Cancer Center,

Amitabh Chak, MD, PRINCIPAL_INVESTIGATOR, University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center

Study Record Dates

2026-01-01