An Examination of Cognitive Fatigue Using Functional Neuroimaging

Description

The purpose of this research study is to investigate the effectiveness of MS Disease modifying medications on cognitive fatigue in persons with relapsing remitting multiple sclerosis (RRMS). Cognitive fatigue is the kind of fatigue that occurs after intense mental concentration as after a session of problem solving.

Conditions

Multiple Sclerosis, Relapsing-Remitting

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Study Overview

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Study Details

Study overview

The purpose of this research study is to investigate the effectiveness of MS Disease modifying medications on cognitive fatigue in persons with relapsing remitting multiple sclerosis (RRMS). Cognitive fatigue is the kind of fatigue that occurs after intense mental concentration as after a session of problem solving.

An Examination of Cognitive Fatigue Using Functional Neuroimaging

An Examination of Cognitive Fatigue Using Functional Neuroimaging

Condition
Multiple Sclerosis, Relapsing-Remitting
Intervention / Treatment

-

Contacts and Locations

West Orange

Kessler Foundation, West Orange, New Jersey, United States, 07052

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age between 18-64.
  • * Relapsing remitting multiple sclerosis
  • * Been newly prescribed a new disease modifying medication for MS (either Zeposia or other high dose oral efficacy medication)
  • * or healthy volunteer who can speak English fluently.
  • * History of head injury, stroke, seizures, or any other significant neurological event other than MS
  • * Flare up of MS symptoms within the past month.
  • * History of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder.
  • * Pacemaker or other implanted electrical device, brain stimulator, aneurysm clip (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and internal hearing aids \[cochlear implants\]), permanent eyeliner, implanted delivery pumps, or shrapnel fragments.
  • * left handed.
  • * Not able to have an MRI

Ages Eligible for Study

18 Years to 64 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Kessler Foundation,

John DeLuca, PhD, PRINCIPAL_INVESTIGATOR, Kessler Foundation

Study Record Dates

2024-12