Testing the Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy

Eligibility Criteria

• 1. Have a diagnosis of cancer.
• 2. Have received an infusion of neurotoxic chemotherapy within the past nine months (could still be on chemotherapy or have already completed chemotherapy; i.e., taxane-, platinum-, vinca alkaloid-, epothilone-, or proteasome inhibitor-based chemotherapy).
• 3. Report one or more symptoms of CIPN at a level of ≥4 on the CIPN symptom inventory on the Screening Form.
• 4. Have an ECOG Performance Status 0-1.
• 5. Have at least six months life expectancy.
• 6. Be at least 18 years of age.
• 7. Be able to read and understand English.
• 8. Be able to provide written informed consent.
• 1. Have physical limitations (e.g., cardiorespiratory, orthopedic, central nervous system) that contraindicate participation in a low to moderate intensity home-based walking and progressive resistance exercise program, according to the patient's physician (e.g., oncologist, primary care) or physician's designee.
• 2. Be identified as in the active or maintenance stage of exercise behavior per the Exercise Stages of Change Question on the Screening Form.
• 3. Have planned surgery or radiation treatment during the course of the study (hormonal and biologic therapy is allowed).
• 4. Have contraindications for MRI scanning, per the MRI safety screening procedures of the MRI facility to be utilized for this participant.
• 5. Are pregnant or have plans to become pregnant during the course of the study. Documentation of pregnancy and use of contraception can be obtained from the medical record.
• 6. Have a current or prior cancer in the central nervous system (spine, brainstem, brain) as this would interfere with assessments of brain functional connectivity.