Acute Intermittent Hypoxia in Traumatic Brain Injury

Description

This study is designed to answer questions related to safety and preliminary efficacy of Acute Intermittent Hypoxia (AIH) in Traumatic Brain Injury (TBI) survivors. First, we aim to establish whether brief reductions in inhaled oxygen concentration can be safely tolerated in TBI survivors. Second, we aim to establish whether there are any effects of AIH on memory, cognition, and motor control. Participants will be monitored closely for any adverse events during these experiments. Data will be analyzed to determine if there is an improvement in key outcomes at any dose level.

Conditions

Brain Injuries, Traumatic

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Study Overview

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Study Details

Study overview

This study is designed to answer questions related to safety and preliminary efficacy of Acute Intermittent Hypoxia (AIH) in Traumatic Brain Injury (TBI) survivors. First, we aim to establish whether brief reductions in inhaled oxygen concentration can be safely tolerated in TBI survivors. Second, we aim to establish whether there are any effects of AIH on memory, cognition, and motor control. Participants will be monitored closely for any adverse events during these experiments. Data will be analyzed to determine if there is an improvement in key outcomes at any dose level.

Safety and Cognitive Effects of Acute Intermittent Hypoxia-Induced Neuroplasticity in Traumatic Brain Injury

Acute Intermittent Hypoxia in Traumatic Brain Injury

Condition
Brain Injuries, Traumatic
Intervention / Treatment

-

Contacts and Locations

Chicago

Shirley Ryan AbilityLab, Chicago, Illinois, United States, 60611

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Aged 18-65 years
  • * A first time, mild to moderate traumatic brain injury (TBI) confirmed by medical records
  • * When available, a Glasgow Coma Scale score between 9-15
  • * Able to use a keyboard
  • * Able to understand and communicate in English
  • * Able to consent independently
  • * Able to leave a research visit with a companion/group transportation
  • * Women of child-bearing age must be comfortable confirming a negative pregnancy prior to participating in the study
  • * Not involved in any other research intervention study testing neurobehavioral functioning
  • * Other neurological diagnoses or a diagnosis of severe psychiatric disorder (e.g., psychosis) or a reported childhood learning disability
  • * Severe aphasia, preventing a participant from understanding the protocol and consent form
  • * Pre-existing hypoxic pulmonary disease
  • * Severe hypertension (\>160/100)
  • * Medically documented history of obstructive lung diseases \[e.g., Chronic obstructive pulmonary disease (COPD) or significant asthma\]
  • * Ischemic cardiac disease
  • * Ineligible to undergo MRI or TMS

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Shirley Ryan AbilityLab,

Jordan Grafman, PhD, PRINCIPAL_INVESTIGATOR, Shirley Ryan AbilityLab

Study Record Dates

2024-11-01