SUSPENDED

The Selective Cytopheretic Device (SCD) for Acute Kidney Injury (AKI) and Hepatorenal Syndrome (HRS) Type I

Conditions

Acute Kidney Injury Hepatorenal Syndrome

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This research study is being done to learn what effect 7 days of treatment with the Selective Cytopheretic Device (SCD) will have on these white blood cells in the bloodstream of patients with hepatorenal syndrome and to learn whether it has any effect on the blood circulation and kidney function.

Official Title

Investigator Initiated Pilot Study to Assess the Safety and Efficacy of a Selective Cytopheretic Device (SCD) to Treat ICU Patients With Acute Kidney Injury (AKI) and Hepatorenal Syndrome (HRS) Type I

Quick Facts

Study Start:2022-06-09

Study Completion:2027-10

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:SUSPENDED

Study ID

NCT04898010

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Cirrhosis with ascites. * Not currently listed for liver transplant. * Worsening renal failure most likely due to Hepatorenal Syndrome Type I with low glomerular filtration rate (GFR). * No sustained improvement in renal function after diuretic withdrawal and expansion of plasma volume with 1.5 liters of plasma expander. * No sustained improvement in renal function or intolerant to treatment with octreotide and /or midodrine. * Able to tolerate regional citrate anticoagulation and continuous renal replacement therapy (CRRT) for 24 hours or greater. * Intent to deliver full supportive care through aggressive management utilizing all available therapies for a minimum of 96 hours. * Receiving medical care in an intensive care unit. * Absence of shock, ongoing bacterial infection and fluid losses, and current treatment with nephrotoxic medications, hepatocellular carcinoma. * Females of child bearing potential who are not pregnant (confirmed by a negative serum pregnancy test) and not lactating if recently post-partum. * Two (2) consecutive intra-circuit Ionized Calcium (iCa) levels \<0.40 Millimoles per liter (mmol/L), at least 30 minutes apart.	* Evidence of chronic kidney disease Stage 4. * Patients with Model for End-Stage Liver Disease (MELD) score \> 40 (since these patients are unlikely to survive a 90-day follow-up period). * Acute or chronic use of circulatory support device. * Mechanical ventilation for greater than 7 consecutive days. * AKI occurring in the setting of burns, obstructive uropathy, allergic interstitial nephritis, acute or rapidly progressive glomerulonephritis, vasculitis, hemolytic uremic syndrome, thrombotic thrombocytopenic purpura (TTP), malignant hypertension, scleroderma renal crisis, atheroembolism, functional or surgical nephrectomy, cyclosporine or tacrolimus nephrotoxicity. No evidence of intrinsic parenchymal renal disorder, ultrasonic evidence of obstructive uropathy or proteinuria greater than 500 mg/day. * Presence of any organ transplant at any time. * Metastatic malignancy which is actively being treated or may be treated by chemotherapy or radiation during the subsequent three-month period after study protocol therapy. * Severe, uncontrolled cardiac disease. * Chronic immunosuppression. * Medical history of HIV or AIDS. * Current Do Not Attempt Resuscitation (DNAR), Allow Natural Death (AND), or withdrawal of care status, or anticipated change in status within the next 7 days. * Patient is moribund or chronically debilitated for whom full supportive care is not indicated. * Dry weight \>150 kg. * Platelet count \<30,000/mm3. * Concurrent enrollment in another interventional clinical trial. Patients enrolled in clinical studies where only measurements and/or samples are taken (i.e., no test device or test drug used) are allowed to participate * Use of any other investigational drug or device within the previous 30 days * Patient is a prisoner.

Inclusion Criteria

Exclusion Criteria

* Cirrhosis with ascites.
* Not currently listed for liver transplant.
* Worsening renal failure most likely due to Hepatorenal Syndrome Type I with low glomerular filtration rate (GFR).
* No sustained improvement in renal function after diuretic withdrawal and expansion of plasma volume with 1.5 liters of plasma expander.
* No sustained improvement in renal function or intolerant to treatment with octreotide and /or midodrine.
* Able to tolerate regional citrate anticoagulation and continuous renal replacement therapy (CRRT) for 24 hours or greater.
* Intent to deliver full supportive care through aggressive management utilizing all available therapies for a minimum of 96 hours.
* Receiving medical care in an intensive care unit.
* Absence of shock, ongoing bacterial infection and fluid losses, and current treatment with nephrotoxic medications, hepatocellular carcinoma.
* Females of child bearing potential who are not pregnant (confirmed by a negative serum pregnancy test) and not lactating if recently post-partum.
* Two (2) consecutive intra-circuit Ionized Calcium (iCa) levels \<0.40 Millimoles per liter (mmol/L), at least 30 minutes apart.

* Evidence of chronic kidney disease Stage 4.
* Patients with Model for End-Stage Liver Disease (MELD) score \> 40 (since these patients are unlikely to survive a 90-day follow-up period).
* Acute or chronic use of circulatory support device.
* Mechanical ventilation for greater than 7 consecutive days.
* AKI occurring in the setting of burns, obstructive uropathy, allergic interstitial nephritis, acute or rapidly progressive glomerulonephritis, vasculitis, hemolytic uremic syndrome, thrombotic thrombocytopenic purpura (TTP), malignant hypertension, scleroderma renal crisis, atheroembolism, functional or surgical nephrectomy, cyclosporine or tacrolimus nephrotoxicity. No evidence of intrinsic parenchymal renal disorder, ultrasonic evidence of obstructive uropathy or proteinuria greater than 500 mg/day.
* Presence of any organ transplant at any time.
* Metastatic malignancy which is actively being treated or may be treated by chemotherapy or radiation during the subsequent three-month period after study protocol therapy.
* Severe, uncontrolled cardiac disease.
* Chronic immunosuppression.
* Medical history of HIV or AIDS.
* Current Do Not Attempt Resuscitation (DNAR), Allow Natural Death (AND), or withdrawal of care status, or anticipated change in status within the next 7 days.
* Patient is moribund or chronically debilitated for whom full supportive care is not indicated.
* Dry weight \>150 kg.
* Platelet count \<30,000/mm3.
* Concurrent enrollment in another interventional clinical trial. Patients enrolled in clinical studies where only measurements and/or samples are taken (i.e., no test device or test drug used) are allowed to participate
* Use of any other investigational drug or device within the previous 30 days
* Patient is a prisoner.

Contacts and Locations

Principal Investigator

Lenar Yessayan

PRINCIPAL_INVESTIGATOR

University of Michigan

Study Locations (Sites)

University of Michigan

Ann Arbor, Michigan, 48109

United States

Collaborators and Investigators

Sponsor: Lenar Yessayan

Lenar Yessayan, PRINCIPAL_INVESTIGATOR, University of Michigan

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-06-09

Study Completion Date2027-10

Study Record Updates

Study Start Date2022-06-09

Study Completion Date2027-10

Terms related to this study

Additional Relevant MeSH Terms

Acute Kidney Injury
Hepatorenal Syndrome