Responses to Live Attenuated Influenza Virus (LAIV) in Chronic Obstructive Pulmonary Disease (COPD)

Eligibility Criteria

• * Age\>40 years old
• * Physician diagnosis of COPD confirmed by post-bronchodilator testing (defined as forced expiratory volume in one second (FEV1)/forced vital capacity (FVC)\< lower limit of normal and FEV1/FVC\<0.70) and FEV1\>30% predicted at screening
• * Free of acute exacerbation of COPD for prior four weeks at time of recruitment
• * Resting oxygen saturation \>94 percent
• * Blood pressure systolic values between 90-160 mm Hg and diastolic between 55-90 mm Hg
• * No nasal symptoms based on questionnaire
• * Willingness and ability to participate in study procedures
• * Completion of informed consent
• * Age\>40 years old
• * Spirometry testing showing normal lung function (defined as pre and post--bronchodilator FEV1/FVC\>=lower limit of normal and FEV1\>80 percent predicted) at screening
• * Resting oxygen saturation \>94 percent
• * Blood pressure systolic values between 90-160 mm Hg and diastolic between 55-90 mm Hg
• * No nasal symptoms based on questionnaire
• * Willingness and ability to participate in study procedures
• * Completion of informed consent
• * Inability or unwillingness to consent
• * Active tobacco or e-cigarette use (within last six months)
• * Active diagnosis of asthma
• * Any regular suppressive antibiotics (i.e., azithromycin)
• * Daily oral prednisone use
• * Any supplemental oxygen use beyond nocturnal oxygen therapy
• * Use of intranasal corticosteroids in the 30 days prior to screening visit
• * Chronic illness associated with immunosuppression (i.e., HIV, malignancy)
• * History of documented or self-reported positive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection requiring hospitalization
• * Receipt of SARS-CoV-2 vaccine within 14 days prior to study screening visit or plan to receive SARS-CoV-2 vaccine from screening visit to 14 days after completion of all study procedures
• * History of epistaxis, prior nasal surgery or anatomical abnormalities
• * Current use of blood thinner beyond full dose aspirin \[e.g., warfarin (coumadin), clopidogrel (Plavix), dabigatran (Pradaxa), rivaroxaban (Xarelto), apixaban (Eliquis)\]
• * Self-reported history of easy bruising or bleeding gums
• * Serological evidence of HIV infection at screening (Positive HIV antibody test)
• * Relative leukopenia (WBC\<4000), neutropenia (Absolute neutrophil count\<2000) or lymphopenia (absolute lymphocyte count\<1500) on screening CBC
• * Respiratory infection (cough, sore throat, sinusitis, fever) within prior 4 weeks
• * Active wheezing at day 0 visit
• * Pregnancy or nursing or women who are currently trying to become pregnant. (All female subjects, except those who have had a hysterectomy with oophorectomy, will undergo urine pregnancy testing on the morning of the screening visit and again on the on Day 0 at the time of arrival to the lab and prior to LAIV administration. A positive pregnancy test will exclude the subject)
• * Use of chronic immunosuppression in the 30 days prior to screening visit
• * History of hypersensitivity, especially anaphylactic reactions, to egg proteins, gentamicin, gelatin, or arginine, or with a reaction to previous influenza vaccination at a severity level precluding the subject's participation as judged by the study physician
• * History of Guillain-Barre syndrome
• * Subjects who will be unable to avoid contact with immunocompromised individuals for 3 weeks after receiving LAIV vaccine
• * Receipt of the LAIV during the current or prior flu vaccine season
• * Physician diagnosed influenza, a positive test for influenza or suspicion of influenza illness in the 18 months prior to enrollment. Suspicion of influenza will be based on the CDC's influenza-like illness case definition ("fever\>100 °F AND cough/sore throat in the absence of a known cause other than influenza. Temperature can be measured in the office or at the home")
• * Any condition that, in the opinion of the study investigator, would compromise the subject's ability to participate in the study