Neurobiological and Psychological Maintenance Mechanisms Associated With Anticipatory Reward in Bulimia Nervosa

Description

The purpose of this investigation is to identify the potentially crucial role of anticipatory reward mechanisms maintaining bulimic behavior (i.e., binge eating and purging) in bulimia nervosa (BN). The research will investigate neural and psychological anticipatory processes in BN, both in the scanner and the natural environment.

Conditions

Bulimia Nervosa

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Study Overview

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Study Details

Study overview

The purpose of this investigation is to identify the potentially crucial role of anticipatory reward mechanisms maintaining bulimic behavior (i.e., binge eating and purging) in bulimia nervosa (BN). The research will investigate neural and psychological anticipatory processes in BN, both in the scanner and the natural environment.

Neurobiological and Psychological Maintenance Mechanisms Associated With Anticipatory Reward in Bulimia Nervosa

Neurobiological and Psychological Maintenance Mechanisms Associated With Anticipatory Reward in Bulimia Nervosa

Condition
Bulimia Nervosa
Intervention / Treatment

-

Contacts and Locations

Minneapolis

University of Minnesota, Minneapolis, Minnesota, United States, 55455

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Right-handed
  • * Ability to read and speak in English
  • * Eating Disorder Examination (EDE) diagnosis of BN (i.e., at least one objective bulimic episode and one self-induced vomiting episode per week for at three months) with binge episodes always accompanied by self-induced vomiting
  • * Stable dose for at least 6 weeks of any recent changes in medication impacting mood, appetite, or weight
  • * No binge eating or purging episodes for the past three months on the EDE
  • * No current or past history of an eating disorder as diagnosed by Structured Clinical Interview for DSM-5 Disorders
  • * History of gastric bypass surgery
  • * Medical condition acutely affecting eating behavior and/or weight (i.e., pregnancy, lactation, thyroid disease)
  • * Current medical or psychiatric instability (i.e., hospitalization required in the past three months)
  • * Lifetime history of psychosis or bipolar disorder
  • * History of neurological disorder or injury (i.e., stoke, head injury with \>10 minutes loss of consciousness)
  • * Current substance use disorder
  • * BMI less than 19 kg/m\^2
  • * Acute suicidality requiring hospitalization
  • * fMRI exclusions as specifiedd by the Center for Magnetic Resonance Research
  • * Food allergy that cannot be accommodated through substitutions to the laboratory test snack

Ages Eligible for Study

18 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Minnesota,

Carol B Peterson, PhD, PRINCIPAL_INVESTIGATOR, University of Minnesota Department of Psychiatry and Behavioral Sciences

Study Record Dates

2024-12-31