Enhancing Language Function in Primary Progressive Aphasia

Description

This study's goal is to use non-invasive brain stimulation (NBS) techniques to treat language impairment associated with Primary Progressive Aphasia (PPA). The purpose of this study is to combine behavioral language intervention with individualized noninvasive brain stimulation techniques, called transcranial direct current stimulation (tDCS) to help the brain reorganize around damage and improve language functions.

Conditions

Primary Progressive Aphasia

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Study Overview

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Study Details

Study overview

This study's goal is to use non-invasive brain stimulation (NBS) techniques to treat language impairment associated with Primary Progressive Aphasia (PPA). The purpose of this study is to combine behavioral language intervention with individualized noninvasive brain stimulation techniques, called transcranial direct current stimulation (tDCS) to help the brain reorganize around damage and improve language functions.

Enhancing Language Function in Primary Progressive Aphasia (PPA) With Transcranial Direct Current Stimulation (tDCS)

Enhancing Language Function in Primary Progressive Aphasia

Condition
Primary Progressive Aphasia
Intervention / Treatment

-

Contacts and Locations

Tucson

University of Arizona, Tucson, Arizona, United States, 85721-0071

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * diagnosed with PPA by neurologist or speech-language pathologist
  • * speech-language deficit arising from PPA
  • * native speaker of English Language or equivalent
  • * adequate vision (normal or corrected to normal)
  • * adequate hearing
  • * meeting (Diagnostic and Statistical Manual) DSM-IV criteria for Axis I mood, anxiety, psychotic or substance abuse disorders.
  • * highly magnetizable metallic implants, including certain dental work
  • * neurological disorders besides the ones of interest for the study (e.g., epilepsy)
  • * Multiple Sclerosis
  • * Parkinson's Disease
  • * contraindications for MRI
  • * pacemakers
  • * metallic cardiac pumps
  • * valves
  • * magnetic materials such as surgical clips, implanted electronic perfusion pumps, or any other condition that would preclude proximity to a strong magnetic field.
  • * clinically significant claustrophobia
  • * severe systemic disease (e.g., renal failure)
  • * poor health
  • * pregnancy
  • * epileptic activity in the past 12 months
  • * family history of epilepsy or other seizure disorders
  • * brain surgery in the past
  • * metallic skull plates or implants
  • * skin lesions or skull damage
  • * excessive use of alcohol or drugs
  • * premorbid psychiatric disease affecting communication
  • * severe non-linguistic cognitive disturbances impeding language therapy

Ages Eligible for Study

45 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Arizona,

Aneta Kielar, PhD, PRINCIPAL_INVESTIGATOR, University of Arizona

Study Record Dates

2027-06-15