RECRUITING

Enhancing Language Function in Primary Progressive Aphasia

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Conditions

Primary Progressive Aphasia

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study's goal is to use non-invasive brain stimulation (NBS) techniques to treat language impairment associated with Primary Progressive Aphasia (PPA). The purpose of this study is to combine behavioral language intervention with individualized noninvasive brain stimulation techniques, called transcranial direct current stimulation (tDCS) to help the brain reorganize around damage and improve language functions.

Official Title

Enhancing Language Function in Primary Progressive Aphasia (PPA) With Transcranial Direct Current Stimulation (tDCS)

Quick Facts

Study Start:2021-08-30
Study Completion:2027-06-15
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04920318

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:45 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * diagnosed with PPA by neurologist or speech-language pathologist
  2. * speech-language deficit arising from PPA
  3. * native speaker of English Language or equivalent
  4. * adequate vision (normal or corrected to normal)
  5. * adequate hearing
  1. * meeting (Diagnostic and Statistical Manual) DSM-IV criteria for Axis I mood, anxiety, psychotic or substance abuse disorders.
  2. * highly magnetizable metallic implants, including certain dental work
  3. * neurological disorders besides the ones of interest for the study (e.g., epilepsy)
  4. * Multiple Sclerosis
  5. * Parkinson's Disease
  6. * contraindications for MRI
  7. * pacemakers
  8. * metallic cardiac pumps
  9. * valves
  10. * magnetic materials such as surgical clips, implanted electronic perfusion pumps, or any other condition that would preclude proximity to a strong magnetic field.
  11. * clinically significant claustrophobia
  12. * severe systemic disease (e.g., renal failure)
  13. * poor health
  14. * pregnancy
  15. * epileptic activity in the past 12 months
  16. * family history of epilepsy or other seizure disorders
  17. * brain surgery in the past
  18. * metallic skull plates or implants
  19. * skin lesions or skull damage
  20. * excessive use of alcohol or drugs
  21. * premorbid psychiatric disease affecting communication
  22. * severe non-linguistic cognitive disturbances impeding language therapy

Contacts and Locations

Study Contact

Aneta Kielar, PhD
CONTACT
15204883791
akielar@email.arizona.edu

Principal Investigator

Aneta Kielar, PhD
PRINCIPAL_INVESTIGATOR
University of Arizona

Study Locations (Sites)

University of Arizona
Tucson, Arizona, 85721-0071
United States

Collaborators and Investigators

Sponsor: University of Arizona

  • Aneta Kielar, PhD, PRINCIPAL_INVESTIGATOR, University of Arizona

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-08-30
Study Completion Date2027-06-15

Study Record Updates

Study Start Date2021-08-30
Study Completion Date2027-06-15

Terms related to this study

Additional Relevant MeSH Terms

  • Primary Progressive Aphasia