In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans

Description

In this study, the investigators hypothesize that THC alters the immunogenome in a cell type-specific fashion and alters cytokine production via epigenetic regulatory mechanisms and that these alterations differ between HIV-infected and HIV-uninfected host genomes.

Conditions

HIV Infections, Healthy

Study Overview

Study Details

Study overview

In this study, the investigators hypothesize that THC alters the immunogenome in a cell type-specific fashion and alters cytokine production via epigenetic regulatory mechanisms and that these alterations differ between HIV-infected and HIV-uninfected host genomes.

In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans

In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans

Condition
HIV Infections
Intervention / Treatment

-

Contacts and Locations

West Haven

VA Connecticut Healthcare System, West Haven, Connecticut, United States, 06516

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to 65 Years

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    Yes

    Collaborators and Investigators

    Yale University,

    Deepak C D'Souza, MD, PRINCIPAL_INVESTIGATOR, Yale University Professor of Psychiatry

    Study Record Dates

    2025-06-30