EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy

Description

This study is a multi-site, cluster randomized, two group implementation trial comparing a low- versus high-intensity implementation strategy for supporting hospital-based opioid use disorder treatment (HBOT) in community hospital settings where medication for opioid use disorder (MOUD) treatment has not been implemented.

Conditions

Substance Use Disorders, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate

Study Overview

Study Details

Study overview

This study is a multi-site, cluster randomized, two group implementation trial comparing a low- versus high-intensity implementation strategy for supporting hospital-based opioid use disorder treatment (HBOT) in community hospital settings where medication for opioid use disorder (MOUD) treatment has not been implemented.

Exemplar Hospital Initiation Trial to Enhance Treatment Engagement - Implementation Trial of High Intensity Versus Low Intensity Strategy for Supporting Hospital-Based Opioid Use Disorder Treatment

EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy

Condition
Substance Use Disorders
Intervention / Treatment

-

Contacts and Locations

Boston

Boston University, Boston, Massachusetts, United States, 02119

Minneapolis

Hennepin Healthcare Research Institute, Minneapolis, Minnesota, United States, 55404

New York

New York University, New York, New York, United States, 10016

Portland

Oregon Health & Science University, Portland, Oregon, United States, 97239

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Be a community hospital deemed by the lead investigators to be in the region of a site/hub. Region will usually be defined as state unless a compelling case can be made as to geographic feasibility of implementing the intervention and access to relevant Medicaid data.
  • 2. Be willing to identify a site champion to promote and adopt change that can address OUD in hospitalized patients.
  • 3. Have hospital personnel who state that their institution is interested in and would be willing to work to implement MOUD prior to hospital discharge.
  • 4. Commit to having buprenorphine-waivered prescribers willing and able to write prescriptions to bridge discharged patients to post-discharge OUD treatment, or available direct entry into outpatient MOUD with methadone or buprenorphine.
  • 5. Have hospital staff who express willingness to engage with a site/hub team for training and for data collection.
  • 6. Be willing to be randomized to low-intensity or high-intensity implementation support.
  • 7. Provide inpatient general medical care.
  • 8. Have sufficient numbers of Medicaid OUD discharges (any listed diagnosis; sufficient is defined as at least enough such that when added to the other hospitals in the region there are on average 100 discharges per year). Medicaid data must capture at least 3 discharge diagnoses, outpatient MOUD, and be available within no more than 12 months of discharge.
  • 1. Have an ACS routinely prescribing MOUD at discharge.
  • 2. Have an existing, functioning HBOT program or be imminently starting an HBOT initiative, as confirmed by the investigator team.
  • 3. Be a Veterans Affairs hospital.

Ages Eligible for Study

to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Hennepin Healthcare Research Institute,

Study Record Dates

2026-04