RECRUITING

Responses to Backward Walking Training Post-Stroke

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Approximately 15,000 Veterans are hospitalized for stroke each year with new cases costing an estimated $111 million for acute inpatient, $75 million for post-acute inpatient, and $88 million for follow-up care over 6 months post-stroke. The investigators have previously established the effectiveness of a backward walking training program to improve gait and balance in post-stroke Veterans. To best serve Veterans in this era of personalized medicine, there is a current need to determine the appropriate training dose as well as which post-stroke Veterans would most benefit. This study addresses both needs as it will 1) test responses to two different doses (18 vs. 27 sessions) of backward walking training and 2) assess brain activity, measured by magnetic resonance imaging, before and after training intervention to determine its ability to predict rehabilitation response as well as brain mechanisms of behavioral change.

Official Title

Brain and Behavioral Responses to Backward Walking Training Post-Stroke

Quick Facts

Study Start:2021-11-08
Study Completion:2025-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04928482

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Berg Balance Scale \< 45
  2. * Self-selected 10 meter gait speed \< 0.8 m/s
  3. * Diagnosis of unilateral stroke
  4. * \> 2 months \< 4 months post-stroke
  5. * Able to ambulate at least 10 feet with maximum 1 person assist
  6. * Medically stable
  1. * Presence of neurological condition other than stroke
  2. * Serious cardiac conditions (hospitalization for myocardial infarction or heart surgery within 3 months, history of congestive heart failure, documented serious and unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during activities of daily living)
  3. * Anyone meeting New York Heart Association criteria for Class 3 or Class 4 heart disease will be excluded
  4. * Severe arthritis or orthopedic problems that limit passive ranges of motion of lower extremity (knee flexion contracture of -10 degrees, knee flexion ROM \< 90 degrees, hip flexion contracture \> 25 degrees, and ankle plantar flexion contracture \> 15 degrees)
  5. * Severe hypertension with systolic greater than 200 mmHg and diastolic greater than 110 mmHg at rest
  6. * Pain upon ambulation
  7. * Receiving physical therapy services for mobility and/or gait
  8. * Living in a skilled nursing facility
  9. * Any MRI contraindication, including but not limited to the presence of metal, MR sensitive implanted medical devices, or claustrophobia

Contacts and Locations

Study Contact

Dorian K Rose, PhD MS BS
CONTACT
(352) 273-8307
Dorian.Rose@va.gov

Principal Investigator

Dorian Kay Rose, PhD MS BS
PRINCIPAL_INVESTIGATOR
North Florida/South Georgia Veterans Health System, Gainesville, FL

Study Locations (Sites)

North Florida/South Georgia Veterans Health System, Gainesville, FL
Gainesville, Florida, 32608-1135
United States
Brooks Rehabilitation
Jacksonville, Florida, 32216
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Dorian Kay Rose, PhD MS BS, PRINCIPAL_INVESTIGATOR, North Florida/South Georgia Veterans Health System, Gainesville, FL

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-11-08
Study Completion Date2025-12-31

Study Record Updates

Study Start Date2021-11-08
Study Completion Date2025-12-31

Terms related to this study

Keywords Provided by Researchers

  • Rehabilitation
  • Gait
  • Physical Therapy Modalities
  • Magnetic Resonance Imaging
  • Postural Balance
  • Accidental Falls

Additional Relevant MeSH Terms

  • Stroke