The Impact of Oral Cannabis Administration and Co-Administration of Alcohol on Impairment

Eligibility Criteria

• 1. Have provided written informed consent
• 2. Be between the ages of 21 and 55
• 3. Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests
• 4. Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and a negative urine pregnancy test at each study visit.
• 5. Have a body mass index (BMI) in the range of 19 to 36 kg/m2
• 6. Blood pressure at Screening Visit does not exceed a systolic blood pressure (SBP) of 150 mmHg or a diastolic blood pressure (DBP) of 90 mmHg
• 7. Have not donated blood in the prior 30 days.
• 8. Report at least 2 days of binge drinking in the past 90 days (greater than 4 or 5 drinks on a single occasion for women and men, respectively)
• 9. Report ≥ 1 use of cannabis in the past year
• 10. Provide negative urine test for illicit drug use (excluding THC) and negative breath alcohol test (0% BAC) at screening and before study sessions
• 11. Report at least 1 instance of simultaneous alcohol and use in the past year.
• 1. Psychoactive drug use (aside from cannabis, nicotine, alcohol, or caffeine) in past month
• 2. Current use of over-the-counter (OTC) drugs, supplements/vitamins, or prescription medications that, in the opinion of the investigator or medical staff, will impact the participant's safety
• 3. History of or current evidence of significant medical condition
• 4. Evidence of current psychiatric condition \[(MINI for Diagnostic and Statistical Manual (DSM)-V)\]
• 5. Meet criteria for severe alcohol use disorder (MINI for DSM-V)
• 6. Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA-Ar) score \> 9
• 7. Been in treatment previously for alcohol or cannabis use disorder
• 8. Use of cannabis, on average, more than 2 times/week over past 3 months
• 9. Liver function tests more than 2x normal range
• 10. Enrollment in another clinical trial or receiving of any drug as part of research within past 30 days
• 11. Shipley vocabulary score \<18 (corresponds to 5th grade reading level).