Breathing Training for Improving Cardiovascular Health in Older Adults With Sleep Apnea

Description

This clinical research study will investigate the effects of respiratory strength training on blood pressure and cardiovascular health in adults who are 50 years of age and older and have been diagnosed with moderate or severe obstructive sleep apnea.

Conditions

Obstructive Sleep Apnea, Hypertension

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Study Overview

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Study Details

Study overview

This clinical research study will investigate the effects of respiratory strength training on blood pressure and cardiovascular health in adults who are 50 years of age and older and have been diagnosed with moderate or severe obstructive sleep apnea.

Time-efficient Inspiratory Muscle Strength Training for Improving Blood Pressure and Vascular Function in Older Adults With Sleep Disordered Breathing

Breathing Training for Improving Cardiovascular Health in Older Adults With Sleep Apnea

Condition
Obstructive Sleep Apnea
Intervention / Treatment

-

Contacts and Locations

Tucson

Arizona Respiratory and Neurophysiology Laboratory, Tucson, Arizona, United States, 85724

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 50 and older
  • * Ability to understand study procedures and to comply with them for the entire length of the study
  • * Ability to provide informed consent;
  • * Willing to accept random assignment to condition
  • * AHI ≥15
  • * Individuals with who are unwilling or unable to adhere to CPAP
  • * Individuals who are adherent to CPAP therapy (i.e., 4 hours/night on 70%/nights over 30 days in the first 3 months of initial usage)
  • * Individuals who are adherent to mandibular advancement device each night
  • * Above-normal SBP (i.e., SBP ≥120)
  • * BMI ≤40 kg/m2
  • * Weight stable in the prior 3 months (\<3.0 kg weight change) and willing to remain weight stable throughout the study
  • * No change in anti-hypertensive medications or other medications (prescription or dosing) in the prior 3 months and willingness to maintain current medication regimen throughout the study
  • * Absence of unstable clinical disease as determined by medical history, physical examination, and blood chemistries
  • * Total cholesterol \<240 mg/dL
  • * Fasting plasma glucose \<300 mg/dL
  • * Age \<50
  • * AHI \<15
  • * Individuals with central or mixed sleep disordered breathing
  • * Severe hypoxemia (\<80% for \>10% of recording time) during sleep
  • * ESS \>15
  • * SBP ≥160 or DBP ≥120
  • * Current smoker
  • * Chronic overt and poorly controlled medical condition (e.g., diabetes, chronic kidney disease, cancer, congestive heart failure)
  • * Cheyne-Stokes Respiration
  • * Alcohol or illegal drug dependence or abuse
  • * Uncontrolled thyroid disease or change in thyroid medication within previous 3 months
  • * Regular/vigorous aerobic exercise (\> 4 bouts/week, \>30 min/bout at high workload \>6 METS)

Ages Eligible for Study

50 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Arizona,

Elizabeth F Bailey, PhD, PRINCIPAL_INVESTIGATOR, University of Arizona

Study Record Dates

2025-09