Effect of Magnesium Sulfate Bolus on Intraoperative Neuromonitoring

Description

Magnesium Sulfate(MgSo4) is increasingly being used as part of the multimodal pain regimen in the perioperative period. The intraoperative neurophysiological monitoring (IONM) is utilized in complex spine and cranial surgeries to assess the functional integrity of the neural pathways. The effect of Magnesium sulfate on IONM has not been studied. This is a prospective, double blind, randomized placebo controlled trial to study the effect of Magnesium sulfate bolus on the amplitude and latency of somatosensory(SSEPs) and motor evoked potentials(MEPs) in patients undergoing surgery requiring IONM.

Conditions

Intraoperative Neurophysiological Monitoring, Magnesium Sulfate

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Study Overview

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Study Details

Study overview

Magnesium Sulfate(MgSo4) is increasingly being used as part of the multimodal pain regimen in the perioperative period. The intraoperative neurophysiological monitoring (IONM) is utilized in complex spine and cranial surgeries to assess the functional integrity of the neural pathways. The effect of Magnesium sulfate on IONM has not been studied. This is a prospective, double blind, randomized placebo controlled trial to study the effect of Magnesium sulfate bolus on the amplitude and latency of somatosensory(SSEPs) and motor evoked potentials(MEPs) in patients undergoing surgery requiring IONM.

Randomized and Placebo Controlled Study to Evaluate the Effect of Magnesium Sulfate on Intraoperative Neuromonitoring.

Effect of Magnesium Sulfate Bolus on Intraoperative Neuromonitoring

Condition
Intraoperative Neurophysiological Monitoring
Intervention / Treatment

-

Contacts and Locations

Loma Linda

Loma linda University Medical Center, Loma Linda, California, United States, 92354

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Magnesium use within the last 2 days, either intravenous or oral supplements.
  • * Patients with known electrolyte imbalances (Sodium \<135 or \>145 mmol/L OR Potassium \< 3.5 or \> 5.0 mmol/L, Magnesium \>1.2 mmol/L.
  • * Severe cardiac or cardiac conduction disorders.
  • * Severe pulmonary disease.
  • * Patients with significant neuromuscular disorders or preexisting motor or sensory deficits other than focal upper limb neuropathy or focal cervical radiculopathy or mild cervical myelopathy.
  • * Severe Renal disease - serum creatinine of \> 2 mg/dl.
  • * Pregnant or breastfeeding patients.
  • * Unable to obtain adequate baseline SSEPs and MEPs.

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Loma Linda University,

Rashmi Vandse, MD, PRINCIPAL_INVESTIGATOR, Loma Linda University

Study Record Dates

2025-12