RECRUITING

Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.

Official Title

Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

Quick Facts

Study Start:2022-07-13
Study Completion:2026-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04940663

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. 18-55 years old
  2. 2. Experienced a psychotic disorder or mood disorder
  1. 1. Any neurological disorder or current substance use disorder (during the past 6 months)
  2. 2. Not proficient in English
  3. 3. A recent change in medication, or an acute symptom presentation
  4. 4. Standard exclusion criteria for participation in an MRI scan (e.g., presence of metal in the body, claustrophobia, a history of head trauma).

Contacts and Locations

Study Contact

Daphne J Holt, MD, PhD
CONTACT
617-726-7618
dholt@partners.org

Principal Investigator

Daphne J Holt, MD, PhD
PRINCIPAL_INVESTIGATOR
Massachusetts General Hospital

Study Locations (Sites)

Massachusetts General Hospital
Charlestown, Massachusetts, 02129
United States

Collaborators and Investigators

Sponsor: Massachusetts General Hospital

  • Daphne J Holt, MD, PhD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-07-13
Study Completion Date2026-06

Study Record Updates

Study Start Date2022-07-13
Study Completion Date2026-06

Terms related to this study

Additional Relevant MeSH Terms

  • Psychosis
  • Schizophrenia