Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * Adults ≥ 18 years of age
- * Approval from the patient's primary inpatient service
- * Hospitalized
- * Diagnosed with COVID-19 pneumonia
- * Positive test for active SARS-CoV-2 infection
- * Requiring supplemental oxygen ≥ 5LNC or ≥ 40% FiO2.
- * Chest computed tomography (CT) at admission with \< 10% pulmonary fibrosis
- * Ability to provide written informed consent on the part of the subject or, in the absence of decisional capacity of the subject, an appropriate surrogate (e.g. a legally authorized representative).
- * Known diagnosis of previous pulmonary fibrosis or an interstitial lung disease.
- * Clinical features or known diagnosis of malignancy or active non-COVID-19 infection, including untreated latent tuberculosis.
- * History of unstable or deteriorating cardiac disease (including myocardial infarction, coronary artery bypass surgery or angioplasty within the past 6 months, congestive heart failure requiring hospitalization within the past 6 months, or uncontrolled arrhythmia.
- * Known history of hypersensitivity to sirolimus.
- * History of unstable or deteriorating neurologic disease (including TIAs or stroke).
- * Pregnant or lactating females. Females of child bearing potential are required to have a negative pregnancy test prior to treatment and practice abstinence or prevent pregnancy by at least a barrier method of birth control.
- * Investigational therapy for any indication within 28 days prior to treatment.
- * Current treatment with any drugs that are strong inhibitors of CYP3A4.
- * Tofacitinib
- * Clarithromycin
- * Telithromycin
- * Nefazodone
- * Itraconazole
- * Ketoconazole
- * Atazanavir
- * Darunavir
- * Indinavir
- * Lopinavir
- * Nelfinavir
- * Ritonavir
- * Saquinavir
- * Tipranavir.
- * Inability or unwillingness to comply with the requirements for the trial.
Ages Eligible for Study
18 Years to
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
No