Ridge Augmentation Using Allograft Particles Hydrated With or Without Recombinant Human Platelet-Derived Growth Factor

Description

This study will compare two techniques to achieve increase in ridge dimensions as a preparation for dental implants using a resorbable barrier membrane and bone particulate allogenic graft hydrated with saline or a growth factor called Recombinant Human Platelet-Derived Growth Factor (rhPDGF).

Conditions

Dental Implant, Bone Loss

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Study Overview

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Study Details

Study overview

This study will compare two techniques to achieve increase in ridge dimensions as a preparation for dental implants using a resorbable barrier membrane and bone particulate allogenic graft hydrated with saline or a growth factor called Recombinant Human Platelet-Derived Growth Factor (rhPDGF).

Lateral Ridge Augmentation Using Allograft Bone Particles Hydrated With or Without Recombinant Human Platelet-Derived Growth Factor: A Clinical and Histological Randomized Controlled Trial

Ridge Augmentation Using Allograft Particles Hydrated With or Without Recombinant Human Platelet-Derived Growth Factor

Condition
Dental Implant
Intervention / Treatment

-

Contacts and Locations

Birmingham

Unversity of Alabama at Birmingham, School of Dentistry, Birmingham, Alabama, United States, 35294-0007

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * English speaking
  • * At least 18 years old
  • * Must be a patient of the UAB Dental School
  • * Able to read and understand informed consent document
  • * Need for implants to replace missing tooth or teeth in at least one quadrant of the mouth.
  • * Insufficient alveolar ridge width for endosseous implant placement defined as 5mm or less as determined by bone sounding and cone beam computed tomography (CBCT) scan.
  • * Non-English speaking
  • * Less than 18 years old
  • * Smokers/tobacco users (\>10 cigarettes/day)
  • * Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing
  • * Patient is a poor compliance risk (i.e., poor oral hygiene, history of alcohol or drug abuse)
  • * Vertical loss of bone at edentulous ridge.

Ages Eligible for Study

18 Years to 99 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Alabama at Birmingham,

Study Record Dates

2025-12