RECRUITING

Exercise for Memory Rehabilitation in Epilepsy

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine how effective a 6-week exercise program is for improving memory compared to a no-intervention control group, investigate the brain changes that may be responsible for memory improvements, and determine if the memory benefits and brain changes are retained 6 weeks after completing the exercise intervention in people with Idiopathic generalized epilepsy (IGE).

Official Title

Exercise for Memory Rehabilitation in Epilepsy

Quick Facts

Study Start:2021-07-21
Study Completion:2026-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04959019

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * males and females
  2. * ages 18-55 years old
  3. * speaks English fluently
  4. * able to provide written informed consent
  5. * have no contraindications to 3-Telsa MRI
  6. * clinician-confirmed diagnosis of IGE (IGE includes epilepsy syndromes such as juvenile myoclonic epilepsy, juvenile absence epilepsy, childhood absence epilepsy, and generalized tonic-clonic seizures alone)
  7. * relatively healthy with no comorbid medical conditions besides epilepsy
  8. * normal pre-enrollment structural clinical MRI of the brain (if available)
  9. * no more than 4 seizure days/month in past 6 months
  10. * having less than the American Heart Association recommendation of physical activity in adults (at least 30 min moderate-intensity aerobic activity at least 5 days/week (150 min total), or at least 25 min vigorous aerobic activity at least 3 days/week (75 min total) and moderate-/high-intensity muscle strengthening activity at least 2 days/week)
  1. * underlying degenerative or metabolic disorders
  2. * abnormal general or neurological examination
  3. * abnormal brain MRI
  4. * recent suicidal ideation in the last 3 months determined based on previous medical history
  5. * pregnant or positive pregnancy test result on the day of the research session
  6. * contraindication to an MRI scan at 3-Telsa
  7. * mental handicap (FSIQ\<80 if tested) or history of special education
  8. * \>4 seizure days/month in past 6 months
  9. * concurrent participation in a different intervention study
  10. * diseased or enlarged heart or blood vessels determined based on previous medical history
  11. * high blood pressure that is not controlled by medications
  12. * meeting the American Heart Association recommendation of physical activity in adults
  13. * abnormal physical examination in which study physician determines subject should not participate in the exercise intervention

Contacts and Locations

Study Contact

Anna Moyana, B.S.
CONTACT
1-205-975-8446
amoyana@uabmc.edu

Principal Investigator

Jane B. Allendorfer, Ph.D.
PRINCIPAL_INVESTIGATOR
University of Alabama at Birmingham

Study Locations (Sites)

University of Alabama at Birmingham
Birmingham, Alabama, 35294
United States

Collaborators and Investigators

Sponsor: University of Alabama at Birmingham

  • Jane B. Allendorfer, Ph.D., PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-07-21
Study Completion Date2026-03-31

Study Record Updates

Study Start Date2021-07-21
Study Completion Date2026-03-31

Terms related to this study

Keywords Provided by Researchers

  • Epilepsy, Idiopathic Generalized
  • Memory Impairment
  • Magnetic Resonance Imaging
  • Neuroimaging
  • Endurance and Resistance Training
  • Resting State Functional Connectivity
  • Verbal Learning and Memory

Additional Relevant MeSH Terms

  • Epilepsy, Generalized
  • Memory Impairment