Exercise for Memory Rehabilitation in Epilepsy

Description

The purpose of this study is to determine how effective a 6-week exercise program is for improving memory compared to a no-intervention control group, investigate the brain changes that may be responsible for memory improvements, and determine if the memory benefits and brain changes are retained 6 weeks after completing the exercise intervention in people with Idiopathic generalized epilepsy (IGE).

Conditions

Epilepsy, Generalized, Memory Impairment

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Study Overview

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Study Details

Study overview

The purpose of this study is to determine how effective a 6-week exercise program is for improving memory compared to a no-intervention control group, investigate the brain changes that may be responsible for memory improvements, and determine if the memory benefits and brain changes are retained 6 weeks after completing the exercise intervention in people with Idiopathic generalized epilepsy (IGE).

Exercise for Memory Rehabilitation in Epilepsy

Exercise for Memory Rehabilitation in Epilepsy

Condition
Epilepsy, Generalized
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35294

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * males and females
  • * ages 18-55 years old
  • * speaks English fluently
  • * able to provide written informed consent
  • * have no contraindications to 3-Telsa MRI
  • * clinician-confirmed diagnosis of IGE (IGE includes epilepsy syndromes such as juvenile myoclonic epilepsy, juvenile absence epilepsy, childhood absence epilepsy, and generalized tonic-clonic seizures alone)
  • * relatively healthy with no comorbid medical conditions besides epilepsy
  • * normal pre-enrollment structural clinical MRI of the brain (if available)
  • * no more than 4 seizure days/month in past 6 months
  • * having less than the American Heart Association recommendation of physical activity in adults (at least 30 min moderate-intensity aerobic activity at least 5 days/week (150 min total), or at least 25 min vigorous aerobic activity at least 3 days/week (75 min total) and moderate-/high-intensity muscle strengthening activity at least 2 days/week)
  • * underlying degenerative or metabolic disorders
  • * abnormal general or neurological examination
  • * abnormal brain MRI
  • * recent suicidal ideation in the last 3 months determined based on previous medical history
  • * pregnant or positive pregnancy test result on the day of the research session
  • * contraindication to an MRI scan at 3-Telsa
  • * mental handicap (FSIQ\<80 if tested) or history of special education
  • * \>4 seizure days/month in past 6 months
  • * concurrent participation in a different intervention study
  • * diseased or enlarged heart or blood vessels determined based on previous medical history
  • * high blood pressure that is not controlled by medications
  • * meeting the American Heart Association recommendation of physical activity in adults
  • * abnormal physical examination in which study physician determines subject should not participate in the exercise intervention

Ages Eligible for Study

18 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Alabama at Birmingham,

Jane B. Allendorfer, Ph.D., PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

2026-03-31