Countermeasures to Circadian Misalignment

Description

Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.

Conditions

Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity

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Study Overview

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Study Details

Study overview

Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.

Time-restricted Feeding to Mitigate Metabolic Impairments During Circadian Misalignment

Countermeasures to Circadian Misalignment

Condition
Circadian Rhythm Sleep Disorder of Shift Work Type
Intervention / Treatment

-

Contacts and Locations

Fort Collins

Colorado State University, Fort Collins, Colorado, United States, 80523

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. 18-35 old; men and women; equal numbers of women and men will be included.
  • 2. Body Mass Index (BMI) between 20.0 and 24.9 ("normal" weight).
  • 3. Physical activity history: inactive to habitual moderate physical activity level
  • 4. Sleep/wake history: habitual sleep duration between 7-9.25 hours.
  • 5. Altitude history: Potential subjects must have lived at Denver altitude or higher for at least 3 months prior to inpatient stay.
  • 1. Any clinically significant medical, psychiatric, or sleep disorder
  • 2. Use of prescribed medications/supplements/illicit drugs within one month prior to study
  • 3. History of shift work in year prior to study, or travel more than one time zone in three weeks prior to study. \[NOTE: Subjects can be studied at a later date.\]
  • 4. Women with history of prior gynecological pathology, \<1 year post-partum, breast-feeding and/or pregnant.
  • 5. Non-English speakers will be excluded, as we do not have access to a translator who could rely accurate information to the participant for the consent or throughout the study.

Ages Eligible for Study

18 Years to 35 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Colorado State University,

Study Record Dates

2025-06-30