RECRUITING

HPV in Sinonasal Ca: Retrospective Analysis Association of Human Papilloma Virus (HPV) Serology and Behavioral Risk Factors

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Conditions

Sinonasal CarcinomaHPV-Related Squamous Cell Carcinoma

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a case-control study designed to evaluate the role of anatomic site, gender and race in human papillomavirus-associated head and neck squamous cell cancers (HNSCC). We will explore the role of HPV, tobacco, alcohol and drug use, in HNSCC by tumor site with particular emphasis on the sinonasal cavity as well as differences in risk factors for HPV-positive HNSCC by gender and race.

Official Title

The Role of High-risk HPV in Sinonasal Carcinomas: a Retrospective Tissue Analysis of the Increasing Frequency and Case-control Study to Evaluate the Association of HPV Serology and Behavioral Risk Factors

Quick Facts

Study Start:2021-08-03
Study Completion:2028-01-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04979000

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Cases:
  2. * Patients must be 18 years of age or older with a confirmed or suspected diagnosis of sinonasal cancer
  3. * Patients must have either a routine diagnostic biopsy of primary tumor or surgical resection planned as part of routine care (to allow for the collection of tumor sample for the study) or grant access to archival material, from a previously performed biopsy.
  4. * Willing to provide 20 mL blood sample
  5. * Ability to understand and the willingness to sign a written informed consent document
  6. * Controls:
  7. * Must be 18 years of age or older within the categories of age, gender, and race needed to match cases
  8. * Ability to understand and the willingness to sign a written informed consent document
  1. * Cases:
  2. * Presence of medical or psychiatric condition affecting ability to give voluntary, informed consent
  3. * Participants who do not speak English and do not agree to use of a telephone or video interpreter will be excluded. However, if there is a hearing, literally or minor fluency issue and the participant requests assistance from a family member or the study coordinator, this individual may still enroll and receive this assistance to ensure they fully hear and understand everything being asked
  4. * Controls:
  5. * Presence of medical or psychiatric condition affecting ability to give voluntary, informed consent
  6. * Participants who do not speak English and do not agree to use of a telephone or video interpreter will be excluded. However, if there is a hearing, literacy or minor fluency issue and the participant requests assistance from a family member or the study coordinator, this individual may still enroll and receive this assistance to ensure they fully hear and understand everything being asked
  7. * No prior diagnosis of head and neck cancer, except basal cell cancer
  8. * No previous radiation therapy of the head and neck

Contacts and Locations

Study Contact

Nyall London, M.D.
CONTACT
301-896-3332
nlondon2@jhmi.edu
Zubair Khan, M.D.
CONTACT
410-955-3157
zkhan@jhmi.edu

Principal Investigator

Nyall London, M.D.
PRINCIPAL_INVESTIGATOR
Department of Otolaryngology and Surgery

Study Locations (Sites)

Johns Hopkins University
Baltimore, Maryland, 21287
United States

Collaborators and Investigators

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

  • Nyall London, M.D., PRINCIPAL_INVESTIGATOR, Department of Otolaryngology and Surgery

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-08-03
Study Completion Date2028-01-30

Study Record Updates

Study Start Date2021-08-03
Study Completion Date2028-01-30

Terms related to this study

Additional Relevant MeSH Terms

  • Sinonasal Carcinoma
  • HPV-Related Squamous Cell Carcinoma