Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * ≥18 years old
- * American Society of Anesthesiologists physical status 1-4
- * Scheduled for major noncardiac surgery expected to last at least 2 hours
- * Expected to remain hospitalized at least two postoperative nights
- * Scheduled for general endotracheal, spinal anesthesia, or the combination
- * Expected to require substantial opioid analgesia, defined as ≥20 mg morphine equivalents
- * Expected to have patient-controlled intravenous analgesia.
- * Are demented or otherwise cannot provide valid consent
- * Have contraindications to oliceridine
- * Used legal or illegal opioids chronically, defined as \>15 mg morphine equivalents for \>15 days during the month before consenting by history
- * Have language, vision, or hearing impairments that may compromise continuous ventilation monitoring
- * Have planned epidural anesthesia/analgesia
- * Planned spinal morphine administration
- * Are designated Do Not Resuscitate, hospice, or receiving end of life therapy
- * Are expected to require postoperative mechanical ventilation or ICU admission
- * Are expected to receive intrathecal opioids
- * Are expected to receive gabapentin, pregabalin or other analgesic adjuvants
- * Use oxygen at home
- * Are unwilling or unable to comply fully with study procedures (including not tolerating the capnography cannula)
- * Are known to be pregnant or breastfeeding
- * Use CPAP at home
- * Have previously participated in the trial
Ages Eligible for Study
18 Years to
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
No