A Randomized Trial of a Mobile Health Exercise Intervention for Older Adults With Myeloid Neoplasms

Description

This is a phase 2 randomized controlled trial (RCT) to assess the preliminary efficacy of the a mobile health exercise intervention (GO-EXCAP) versus a chemotherapy education control in 100 older patients with MN receiving outpatient chemotherapy on physical function and patient-reported outcomes (fatigue, mood, and quality of life). We will also explore the effect of the intervention on TNFα and related cytokine gene promoter methylation and their gene and protein expression.

Conditions

Cancer, Myeloid Neoplasm

Study Overview

Study Details

Study overview

This is a phase 2 randomized controlled trial (RCT) to assess the preliminary efficacy of the a mobile health exercise intervention (GO-EXCAP) versus a chemotherapy education control in 100 older patients with MN receiving outpatient chemotherapy on physical function and patient-reported outcomes (fatigue, mood, and quality of life). We will also explore the effect of the intervention on TNFα and related cytokine gene promoter methylation and their gene and protein expression.

A Pilot Randomized Trial of a Mobile Health Exercise Intervention for Older Adults With Myeloid Neoplasms

A Randomized Trial of a Mobile Health Exercise Intervention for Older Adults With Myeloid Neoplasms

Condition
Cancer
Intervention / Treatment

-

Contacts and Locations

Rochester

University of Rochester Medical Center/Wilmot Cancer Institute, Rochester, New York, United States, 14642

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥60 years (conventional definition of older age in clinical trials of MN)
  • * Have a diagnosis of MN
  • * Planned for or receiving outpatient cancer-directed treatments (patients receiving consolidative or maintenance outpatient therapies after induction chemotherapy are allowed to enroll)
  • * English speaking
  • * Eastern Cooperative Oncology Group (ECOG) performance status of 0-3
  • * No medical contraindications for exercise per oncologist
  • * Able to walk 4 meters as part of Short Physical Performance Battery measured walk (with or without assistive device)
  • * Able to provide informed consent
  • * Physical, psychological, or social impairments that would interfere with patient's ability to participate in the study or participate in the intervention, as determined by the PI or the treating team

Ages Eligible for Study

60 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Rochester,

Kah Poh Loh, PRINCIPAL_INVESTIGATOR, University of Rochester

Study Record Dates

2025-12-31