Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder

Description

This is a proof-of-concept randomized clinical trial of psilocybin-enhanced psychotherapy versus treatment-as-usual among individuals being treated for methamphetamine use disorder.

Conditions

Amphetamine-Related Disorders

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Study Overview

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Study Details

Study overview

This is a proof-of-concept randomized clinical trial of psilocybin-enhanced psychotherapy versus treatment-as-usual among individuals being treated for methamphetamine use disorder.

Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder

Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder

Condition
Amphetamine-Related Disorders
Intervention / Treatment

-

Contacts and Locations

Vancouver

Portland VA Health Care System, Vancouver, Washington, United States, 98661

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * United States military Veteran
  • * Moderate to severe methamphetamine use disorder using the DSM-V diagnostic criteria
  • * Desire to cease or reduce methamphetamine use
  • * Have uncontrolled hypertension or clinically significant cardiovascular disease
  • * History of seizure disorder in adulthood
  • * CNS metastases or symptomatic central nervous system (CNS) infection
  • * Poorly controlled diabetes mellitus
  • * Taking certain medications that may interact with psilocybin
  • * History of any primary persistent psychotic disorder, including schizophrenia, schizoaffective disorder, bipolar disorder with psychosis, major depressive disorder with psychosis, or schizophreniform disorder
  • * History of bipolar I disorder
  • * Current eating disorder with active purging
  • * History of hallucinogen use disorder
  • * Pregnant or breast feeding

Ages Eligible for Study

25 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Portland VA Research Foundation, Inc,

Chris Stauffer, MD, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

2025-04-30