Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children

Description

The over-arching aim of this study is to evaluate the effects of two specific anti-cancer chemotherapies, vincristine and doxorubicin, on bladder function and urine composition.

Conditions

Survivors of Childhood Cancer, Bladder Dysfunction

Talk to us

Study Overview

On this page

Study Details

Study overview

The over-arching aim of this study is to evaluate the effects of two specific anti-cancer chemotherapies, vincristine and doxorubicin, on bladder function and urine composition.

Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children

Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children

Condition
Survivors of Childhood Cancer
Intervention / Treatment

-

Contacts and Locations

Aurora

Children's Hospital Colorado, Aurora, Colorado, United States, 80045

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Children aged 5-13 years old
  • * A history of cancer
  • * Treatment with a chemotherapy regimen including VCR and/or DOX
  • * Completion of chemotherapy at least one year prior to study enrollment and survey completion.
  • * Patients with a:
  • * Primary pelvic tumor
  • * Pelvic irradiation
  • * Pre-existing bladder/bowel dysfunction
  • * Spinal defects
  • * Neurologic disorder
  • * Neuro-oncologic tumor or brain metastasis
  • * Cyclophosphamide or ifosfamide therapy

Ages Eligible for Study

5 Years to 13 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Colorado, Denver,

Nicholas Cost, MD, PRINCIPAL_INVESTIGATOR, Children's Hospital Colorado

Study Record Dates

2026-07-09