RECRUITING

Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Abdominal pain in chronic pancreatitis (CP) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable. The proposed clinical trial will evaluate the predictive capability of Pancreatic Quantitative Sensory Testing (P-QST) - a novel assessment of neurosensory phenotyping- for improvement in pain in patients with CP who are undergoing medically-indicated invasive treatment with endoscopic therapy or surgery.

Official Title

Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

Quick Facts

Study Start:2022-01-04
Study Completion:2026-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04996628

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adult patients ≥ 18 years of age with definite CP undergoing decompressive invasive treatments (endoscopic therapy or surgery) to relieve main pancreatic duct obstruction due to stones and/or stricture for management of pain.
  2. * Endoscopic therapy: Endoscopic Retrograde Cholangiopancreatography (ERCP) with pancreatic duct stone removal, stent placement, and/or stricture dilation, ± intraductal lithotripsy or Extracorporeal Shock Wave Lithotripsy (ESWL).
  3. * Surgery: drainage procedures (Frey and Puestow operations)
  1. * Patients with chronic pain from conditions other than CP
  2. * Patients \< 18 years of age
  3. * Patients who have had endoscopic therapy within the past 12 months
  4. * Patients who have undergone prior pancreatic surgery
  5. * Patients who have resective surgical procedure planned (eg. Whipple procedure, Total Pancreatectomy)
  6. * Patients with peripheral sensory deficits
  7. * Patients with known pregnancy at the time of study screening\*\*
  8. * Note: Women who become pregnant during the course of the study can no longer participate in P-QST testing.

Contacts and Locations

Study Contact

Anna Evans Phillips, MD, MS
CONTACT
412-647-2345
evansac3@upmc.edu
Apsara Mishra
CONTACT
apm179@pitt.edu

Principal Investigator

Anna Evans Phillips, MD, MS
PRINCIPAL_INVESTIGATOR
University of Pittsburgh

Study Locations (Sites)

Indiana University Medical Center
Indianapolis, Indiana, 46202
United States
Johns Hopkins Medical Institutions
Baltimore, Maryland, 21287
United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: University of Pittsburgh

  • Anna Evans Phillips, MD, MS, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-01-04
Study Completion Date2026-06-30

Study Record Updates

Study Start Date2022-01-04
Study Completion Date2026-06-30

Terms related to this study

Keywords Provided by Researchers

  • Chronic Pain
  • Chronic Pancreatitis
  • Recurrent Acute Pancreatitis
  • Chronic Abdominal Pain
  • ERCP
  • Pancreatic Surgery

Additional Relevant MeSH Terms

  • Chronic Pancreatitis
  • Chronic Pain