Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

Description

Abdominal pain in chronic pancreatitis (CP) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable. The proposed clinical trial will evaluate the predictive capability of Pancreatic Quantitative Sensory Testing (P-QST) - a novel assessment of neurosensory phenotyping- for improvement in pain in patients with CP who are undergoing medically-indicated invasive treatment with endoscopic therapy or surgery.

Conditions

Chronic Pancreatitis, Chronic Pain

Talk to us

Study Overview

On this page

Study Details

Study overview

Abdominal pain in chronic pancreatitis (CP) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable. The proposed clinical trial will evaluate the predictive capability of Pancreatic Quantitative Sensory Testing (P-QST) - a novel assessment of neurosensory phenotyping- for improvement in pain in patients with CP who are undergoing medically-indicated invasive treatment with endoscopic therapy or surgery.

Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

Condition
Chronic Pancreatitis
Intervention / Treatment

-

Contacts and Locations

Indianapolis

Indiana University Medical Center, Indianapolis, Indiana, United States, 46202

Baltimore

Johns Hopkins Medical Institutions, Baltimore, Maryland, United States, 21287

Pittsburgh

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult patients ≥ 18 years of age with definite CP undergoing decompressive invasive treatments (endoscopic therapy or surgery) to relieve main pancreatic duct obstruction due to stones and/or stricture for management of pain.
  • * Endoscopic therapy: Endoscopic Retrograde Cholangiopancreatography (ERCP) with pancreatic duct stone removal, stent placement, and/or stricture dilation, ± intraductal lithotripsy or Extracorporeal Shock Wave Lithotripsy (ESWL).
  • * Surgery: drainage procedures (Frey and Puestow operations)
  • * Patients with chronic pain from conditions other than CP
  • * Patients \< 18 years of age
  • * Patients who have had endoscopic therapy within the past 12 months
  • * Patients who have undergone prior pancreatic surgery
  • * Patients who have resective surgical procedure planned (eg. Whipple procedure, Total Pancreatectomy)
  • * Patients with peripheral sensory deficits
  • * Patients with known pregnancy at the time of study screening\*\*
  • * Note: Women who become pregnant during the course of the study can no longer participate in P-QST testing.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pittsburgh,

Anna Evans Phillips, MD, MS, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

2026-06-30