RECRUITING

Speech Perception and High Cognitive Demand

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

With advancing age, adults experience increasing speech understanding difficulties in challenging situations. Currently, speech-in-noise difficulties are rehabilitated by providing hearing aids. For older normal-hearing adults, however, hearing devices do not provide much benefit since these adults do not have decreased hearing sensitivity. The goal of the "Speech Perception and High Cognitive Demand" project is to evaluate the benefit of a new auditory-cognitive training paradigm. In the present study neural (as measured by pupillometry and magnetoencephalography) and behavioral changes of speech-in-noise perception from pretest to posttest will be examined in older adults (age 65 - 85 years) assigned to one of three training groups: 1) Active Control Group: sessions of watching informational videos, 2) Auditory Training Group: sessions of auditory training listening to one of two speakers in everyday scenarios (e.g., driving directions) and needing to recall what one speaker said in the previous sentence, and 3) Auditory-cognitive training group: identical to the auditory training group, except participants will be asked to remember information from two previous sentences. Changes in speech-in-noise perception will be examined for the three groups of older adults and gains will be compared to a control group of young, normal hearing adults (18-30 years) that is not part of the clinical trial and will not undergo any training.

Official Title

Auditory-cognitive Training Paradigm (NIH P01 Project - Speech Perception With High Cognitive Demand)

Quick Facts

Study Start:2021-09-27
Study Completion:2024-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04997577

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Aged between 65 - 85 years
  2. * Normal hearing (pure tone thresholds ≤ 25 dB HL from 250 - 8000 Hz)
  3. * Self-reported normal or corrected-to-normal vision
  4. * Dominant language: American English
  5. * Education: a high school diploma or higher education level
  1. * Middle-ear or inner-ear pathology
  2. * Non-native speaker of English
  3. * Inability to complete all training sessions within a pre-specified time window (e.g., due to unexpected schedule restrictions)
  4. * Learning disorders
  5. * Metal in body that induces a data artifact for MEG recording (e.g., excessive metal dental work) or that poses a safety issue in the MRI portion (e.g., pacemakers, neural implants, metal plates or joints, shrapnel, and surgical staples)
  6. * Claustrophobia or any condition that would be exacerbated by the scanning environment's lighting, sounds, etc. (e.g., migraines)
  7. * A non-removable hairstyle or hair accessory that would prevent the participant from fitting comfortably in the MEG or MRI head coil
  8. * Currently under a medical provider's care for a closed head injury
  9. * Currently taking psychoactive stimulant (e.g., amphetamines), depressant (e.g., benzodiazepines), mood stabilizing (e.g., lithium), anti-psychotic, or anti-seizure medications or drugs of abuse
  10. * Currently pregnant (only for MRI)

Contacts and Locations

Study Contact

Jonathan Z Simon, PhD
CONTACT
301-405-3645
jzsimon@umd.edu
Michael A Johns, PhD
CONTACT
301-405-9604
maj@umd.edu

Principal Investigator

Samira B Anderson, PhD
PRINCIPAL_INVESTIGATOR
University of Maryland, College Park
Jonathan Z Simon, PhD
PRINCIPAL_INVESTIGATOR
University of Maryland, College Park
Stefanie E Kuchinsky, PhD
PRINCIPAL_INVESTIGATOR
Walter Reed National Military Medical Center

Study Locations (Sites)

Department of Hearing and Speech Sciences
College Park, Maryland, 20742
United States
Maryland Neuroimaging Center
College Park, Maryland, 20742
United States

Collaborators and Investigators

Sponsor: University of Maryland, College Park

  • Samira B Anderson, PhD, PRINCIPAL_INVESTIGATOR, University of Maryland, College Park
  • Jonathan Z Simon, PhD, PRINCIPAL_INVESTIGATOR, University of Maryland, College Park
  • Stefanie E Kuchinsky, PhD, PRINCIPAL_INVESTIGATOR, Walter Reed National Military Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-09-27
Study Completion Date2024-12-31

Study Record Updates

Study Start Date2021-09-27
Study Completion Date2024-12-31

Terms related to this study

Keywords Provided by Researchers

  • Auditory-cognitive training
  • Aging
  • Speech-in-noise perception

Additional Relevant MeSH Terms

  • Speech Intelligibility
  • Aging