RECRUITING

Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?

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Conditions

Subarachnoid HemorrhageIntracerebral HemorrhageVentriculitis, CerebralHydrocephalusVentriculitis

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The length of prophylactic antibiotic use with antibiotic impregnated External Ventricular Drains (EVD)s is unknown. This study is a randomized clinical trial with two arms: 1. twenty four hours of prophylactic antibiotic use or 2. prophylactic antibiotic use for entire duration of EVD

Official Title

Are Long Term Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?

Quick Facts

Study Start:2021-06-14
Study Completion:2026-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05001750

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 99 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * patients over the age of 18 years and patients diagnosed with a subarachnoid hemorrhage, intracerebral hemorrhage or acute ischemic stroke who require an EVD for management of their underlying condition.
  2. * In certain cases (a small minority), an EVD must be replaced due to failure (i.e.; blood clot interrupting flow). In such cases, patients will be re-dosed with antibiotics prior to catheter exchange in typical fashion, and continue in their previously randomized treatment group.
  1. * patients who underwent any intracranial procedure in the 30 days prior,
  2. * patients who were on antibiotics within the week prior to admission,
  3. * patients with leukopenia (\<5000) at baseline,
  4. * patients with signs of meningitis, ventriculitis or any other infection at presentation,
  5. * patients who are pregnant or prisoners.
  6. * patients aged \< 18 years old

Contacts and Locations

Study Contact

David C Altschul, MD
CONTACT
7189204965
daltschul@montefiore.org
Erida C Rivas
CONTACT
7189204965
ecastroriv@montefiore.org

Principal Investigator

David C Altschul, MD
PRINCIPAL_INVESTIGATOR
Montefiore Medical Center

Study Locations (Sites)

Montefiore Medical Center
Bronx, New York, 10452
United States

Collaborators and Investigators

Sponsor: Montefiore Medical Center

  • David C Altschul, MD, PRINCIPAL_INVESTIGATOR, Montefiore Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-06-14
Study Completion Date2026-06

Study Record Updates

Study Start Date2021-06-14
Study Completion Date2026-06

Terms related to this study

Keywords Provided by Researchers

  • Subarachnoid hemorrhage
  • Intracerebral Hemorrhage
  • Ventriculitis
  • Hydrocephalus

Additional Relevant MeSH Terms

  • Subarachnoid Hemorrhage
  • Intracerebral Hemorrhage
  • Ventriculitis, Cerebral
  • Hydrocephalus