RECRUITING

Comparison Neuromuscular Blockade Monitors

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The overall objective of this research is to evaluate different laboratory-built and commercially available sensors used to measure the effects of neuromuscular blocking drugs on neuromuscular function during surgery, by measuring evoked thumb twitch response to ulnar nerve stimulation (also known as "twitch monitoring"). The specific aim is to compare mechanomyography, which is the "gold standard" laboratory measurement to assess neuromuscular blockade, to the sensors used in commercially available neuromuscular blockade monitors, such as acceleromyography and electromyography. The study endpoints are the train-of-four count (TOFC), the ratio of the height of the 4th twitch to the height of the 1st twitch (train-of-four ratio, TOFR), and the post tetanic count (PTC). The mechanomyography devices have been constructed in our laboratory and are not commercially available.

Official Title

Comparative Assessment of Neuromuscular Blockade Monitors

Quick Facts

Study Start:2022-02-01
Study Completion:2024-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05006807

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 100 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. 18 years of age or greater
  2. 2. Undergoing anesthesia that requires neuromuscular blocking drugs
  1. 1. Less than 18 years of age
  2. 2. Undergoing anesthesia that does not require neuromuscular blocking drugs
  3. 3. Undergoing a procedure in which access to one or both arms is limited
  4. 4. Anatomical abnormalities of the hands or arms that preclude twitch monitoring with ulnar nerve stimulation and evoked thumb twitch response

Contacts and Locations

Study Contact

Lisa Flint
CONTACT
206 543-7817
lyflint@uw.edu

Principal Investigator

T. Andrew Bowdle, MD, PhD
PRINCIPAL_INVESTIGATOR
University of Washington

Study Locations (Sites)

University of Washington Medical Center
Seattle, Washington, 98195
United States

Collaborators and Investigators

Sponsor: University of Washington

  • T. Andrew Bowdle, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Washington

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-02-01
Study Completion Date2024-06-30

Study Record Updates

Study Start Date2022-02-01
Study Completion Date2024-06-30

Terms related to this study

Additional Relevant MeSH Terms

  • Neuromuscular Blockade