RECRUITING

MRI Markers of Feedback Timing During Learning in Individuals with TBI with and Without Clinical Depression

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Conditions

Traumatic Brain InjuryMajor Depressive DisorderfMRILearningMemoryFeedbackRehabilitation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this proposal is to examine the influence of feedback timing on learning and brain function in individuals with moderate-to-severe traumatic brain injury (TBI), with and without depression.

Official Title

MRI Markers of Feedback Timing During Learning in Individuals with TBI with and Without Clinical Depression

Quick Facts

Study Start:2021-09-01
Study Completion:2026-01-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05009511

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * I am between the ages of 18 and 65.
  2. * I have been diagnosed with a TBI.
  3. * I am an individual without TBI.
  4. * I am right-handed.
  5. * I have normal vision or corrected to normal vision.
  6. * I can read and speak English fluently.
  7. * I do or do not have a current diagnosis of Depression.
  8. * I am not currently pregnant.
  1. * I have had a neurological disease, other than TBI.
  2. * I have a significant history of alcohol or drug abuse as determined by study staff.
  3. * I have metal in my body (shrapnel, piercing that cannot be taken off, retainer on the upper jaw).
  4. * I have something in my body that restricts me from having an MRI such as: an aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or auto-defibrillator; cochlear implant (internal hearing aids); ocular foreign body (e.g. metal shavings in my eye), insulin pump or any pre- existing eye conditions (such as blurry vision, seeing double, and abnormal eye movements).
  5. * I experience discomfort in closed spaces (claustrophobia).
  6. * I have been diagnosed with a neurologic illness such as epilepsy, brain tumors, etc. (e.g. schizophrenia and bipolar disorder).
  7. * I have had corticosteroid treatment less than a month ago as determined by study staff review of my medications.
  8. * I have been informed by my doctor that is it unsafe for me to receive regular MRI as part of my medical care.

Contacts and Locations

Study Contact

Julia McMillan, BA
CONTACT
973-323-3684
jmcmillan@kesslerfoundation.org
Belinda Washington, BA
CONTACT
973-324-8446
bwashington@kesslerfoundation.org

Principal Investigator

Ekaterina Dobryakova, PHD
PRINCIPAL_INVESTIGATOR
Kessler Foundation

Study Locations (Sites)

Kessler Foundation
West Orange, New Jersey, 07052
United States

Collaborators and Investigators

Sponsor: Kessler Foundation

  • Ekaterina Dobryakova, PHD, PRINCIPAL_INVESTIGATOR, Kessler Foundation

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-09-01
Study Completion Date2026-01-31

Study Record Updates

Study Start Date2021-09-01
Study Completion Date2026-01-31

Terms related to this study

Keywords Provided by Researchers

  • fMRI
  • Traumatic Brain Injury
  • Major Depressive Disorder
  • Learning
  • Memory
  • Feedback
  • Rehabilitation

Additional Relevant MeSH Terms

  • Traumatic Brain Injury
  • Major Depressive Disorder