MRI Markers of Feedback Timing During Learning in Individuals with TBI with and Without Clinical Depression

Description

The goal of this proposal is to examine the influence of feedback timing on learning and brain function in individuals with moderate-to-severe traumatic brain injury (TBI), with and without depression.

Conditions

Traumatic Brain Injury, Major Depressive Disorder

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Study Overview

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Study Details

Study overview

The goal of this proposal is to examine the influence of feedback timing on learning and brain function in individuals with moderate-to-severe traumatic brain injury (TBI), with and without depression.

MRI Markers of Feedback Timing During Learning in Individuals with TBI with and Without Clinical Depression

MRI Markers of Feedback Timing During Learning in Individuals with TBI with and Without Clinical Depression

Condition
Traumatic Brain Injury
Intervention / Treatment

-

Contacts and Locations

West Orange

Kessler Foundation, West Orange, New Jersey, United States, 07052

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * I am between the ages of 18 and 65.
  • * I have been diagnosed with a TBI.
  • * I am an individual without TBI.
  • * I am right-handed.
  • * I have normal vision or corrected to normal vision.
  • * I can read and speak English fluently.
  • * I do or do not have a current diagnosis of Depression.
  • * I am not currently pregnant.
  • * I have had a neurological disease, other than TBI.
  • * I have a significant history of alcohol or drug abuse as determined by study staff.
  • * I have metal in my body (shrapnel, piercing that cannot be taken off, retainer on the upper jaw).
  • * I have something in my body that restricts me from having an MRI such as: an aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or auto-defibrillator; cochlear implant (internal hearing aids); ocular foreign body (e.g. metal shavings in my eye), insulin pump or any pre- existing eye conditions (such as blurry vision, seeing double, and abnormal eye movements).
  • * I experience discomfort in closed spaces (claustrophobia).
  • * I have been diagnosed with a neurologic illness such as epilepsy, brain tumors, etc. (e.g. schizophrenia and bipolar disorder).
  • * I have had corticosteroid treatment less than a month ago as determined by study staff review of my medications.
  • * I have been informed by my doctor that is it unsafe for me to receive regular MRI as part of my medical care.

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Kessler Foundation,

Ekaterina Dobryakova, PHD, PRINCIPAL_INVESTIGATOR, Kessler Foundation

Study Record Dates

2026-01-31