[C-11]NPA PET-amphetamine in Cocaine Use Disorders

Eligibility Criteria

• 1. Males or females between 18 and 55 years old
• 2. Fulfil DSM-5 criteria for cocaine use disorder
• 3. No other current DSM-5 psychiatric or addictive disorders (such as major depressive disorder, bipolar disorders, psychotic disorders, etc.,)
• 4. No current abuse (six months) of opiates, sedative-hypnotics, amphetamines, and MDMA as well as moderate to severe alcohol or cannabis use (twice a week). Nicotine use will be quantified and controlled between groups using the Fagerstrom Test for Nicotine Dependence (Heatherton et al., 1991);
• 5. Not currently on prescription medical or psychotropic medications
• 6. No current or past severe medical, endocrine or neurological illnesses including glaucoma, seizure disorders, hypertension, hypercholesterolemia as assessed by a complete medical history and physical
• 7. Not currently pregnant or breastfeeding
• 8. No history of significant radioactivity exposure in past year from another research study or occupation that exceeds RDRC guidelines
• 9. No metallic objects in the body that are contraindicated for MRI
• 10. No baseline BP ≥ 140/90 and/or HR ≥ 100.
• 11. No first-degree relative with an MI or stroke prior to middle age
• 12. No first-degree relative with psychosis or mania.
• 13. Completed a baseline \[11C\]NOP-1A PET scan in Aim 1 (Study Record: Imaging CRF X NOP interactions in Cocaine Use Disorders)