Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease

Description

The purpose of this study is to assess how alternating-frequency Deep Brain Stimulation (DBS) works to improve postural instability and gait, while also treating other motor symptoms of Parkinson Disease (PD).

Conditions

Parkinson Disease, Gait Disorders, Neurologic, Disease Progression, Subthalamic Nucleus, Accidental Fall, Deep Brain Stimulation

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Study Overview

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Study Details

Study overview

The purpose of this study is to assess how alternating-frequency Deep Brain Stimulation (DBS) works to improve postural instability and gait, while also treating other motor symptoms of Parkinson Disease (PD).

ENGAGE-PD: Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease

Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease

Condition
Parkinson Disease
Intervention / Treatment

-

Contacts and Locations

Cleveland

Cleveland Clinic Foundation, Cleveland, Ohio, United States, 44195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Bilateral STN DBS for PD
  • * Medtronic Percept PC implanted DBS battery/pulse generator/recording system
  • * Presence of balance and/or walking impairment and/or freezing of gait
  • * Can walk without assistance, OFF meds, based on yes/no verbal response
  • * Severity of gait impairment should not require dependency to walker or cane
  • * Cannot tolerate monopolar stimulation at either of the two middle electrode contacts (prerequisite for the recording mode of the DBS) at high frequency (130 Hz) or low frequency (60 Hz).
  • * Concomitant conditions that may affect significantly the evaluation of balance or gait, including orthopedic, rheumatologic or other neurological diseases
  • * Contraindication to physical therapy
  • * Age \< 21
  • * Diagnosis of dementia
  • * Not agreeable to having video taken of entire research visit

Ages Eligible for Study

21 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

James Liao,

James Liao, MD PhD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Study Record Dates

2025-07