RECRUITING

Antiseptic Effects on the Dental Implant Internal Surface Microbiome

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion. Microbiome-associated complications that result in bone loss, including the micro-leakage of bacterial species proliferating in the dental implant internal cavity, frequently lead to implant failure. Reduction in implant bacterial load may result in a shift of the composition of the microbiome in favor of less pathogenic species, potentially improving dental implant success rates, reducing surgical revisions, and associated cost savings. This study aims to determine how disinfectant gel (hydrogen peroxide or chlorhexidine) insertion into dental implant internal cavities affects implant failure rates, bacterial load and microbiome composition.

Official Title

Antiseptic Effects on the Dental Implant Internal Surface Microbiome

Quick Facts

Study Start:2022-07-28
Study Completion:2024-04
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05024760

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Active duty military
  2. * 18-55 years old
  3. * Over 6 months remaining at local duty station
  1. * Tobacco user
  2. * Medications that affect soft tissue or bone healing
  3. * Metabolic disorder that affects soft tissue or bone healing
  4. * Active periodontal disease

Contacts and Locations

Study Contact

Kevin D Smith, DMD
CONTACT
253-968-0181
kevin.d.smith2.mil@health.mil
Zachary T Colburn, PhD
CONTACT
253-968-3455
zachary.t.colburn.civ@health.mil

Study Locations (Sites)

Madigan Army Medical Center
Tacoma, Washington, 98431
United States

Collaborators and Investigators

Sponsor: Madigan Army Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-07-28
Study Completion Date2024-04

Study Record Updates

Study Start Date2022-07-28
Study Completion Date2024-04

Terms related to this study

Additional Relevant MeSH Terms

  • Peri-Implantitis
  • Peri-implant Mucositis
  • Implant Infection
  • Dental Implant Failed