HA35 Acute Alcohol Study

Description

Eligible subjects will be asked to take a placebo/treatment capsule for a total of 3 days and then participate in a study visit on the fourth day. This study visit will include a medical exam, clinical labs, questionnaires, body composition measurements, and urine and stool collections. Additionally, participants will consume a sugar cocktail to measure their gut permeability, participate in an acute ethanol challenge, and undergo two muscle biopsies. The study will take approximately 3-4 hours and a designated driver will need to drive the participant home. On the fifth day, you will be asked to return to drop of the 24-hour urine collection.

Conditions

Healthy Controls

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Study Overview

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Study Details

Study overview

Eligible subjects will be asked to take a placebo/treatment capsule for a total of 3 days and then participate in a study visit on the fourth day. This study visit will include a medical exam, clinical labs, questionnaires, body composition measurements, and urine and stool collections. Additionally, participants will consume a sugar cocktail to measure their gut permeability, participate in an acute ethanol challenge, and undergo two muscle biopsies. The study will take approximately 3-4 hours and a designated driver will need to drive the participant home. On the fifth day, you will be asked to return to drop of the 24-hour urine collection.

Mechanisms by Which HA35 Regulates Muscle Protein Homeostasis in Healthy Controls

HA35 Acute Alcohol Study

Condition
Healthy Controls
Intervention / Treatment

-

Contacts and Locations

Cleveland

Cleveland Clinic, Cleveland, Ohio, United States, 44195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Alcohol consumption of less than 7 drinks per week for women and less than 14 drinks per week for men
  • * Ability to understand and willingness to provide written consent
  • * Any known chronic illness including but not limited to cancer (except non-melanoma skin cancer)
  • * Poorly controlled diabetes (Hemoglobin A1c \>9.5 g/dl)
  • * Untreated hyper/hypothyroidism
  • * Uncontrolled hypertension or hypercholesterolemia
  • * End-stage renal disease
  • * Liver disease of any etiology
  • * Coronary artery disease or stroke
  • * Active intravenous drug use
  • * History of gastric bypass
  • * Medications known to alter muscle protein synthesis (systemic corticosteroids, tamoxifen, high dose estrogen, testosterone, or anabolic steroids)
  • * Pregnancy
  • * Past alcohol use disorder
  • * Abnormal clotting factors

Ages Eligible for Study

21 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

The Cleveland Clinic,

Study Record Dates

2026-10-01