Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

Description

Evaluate individual differences in the expression of opioid withdrawal symptoms in persons with opioid use disorder (OUD) while completing a clinically-indicated medication taper.

Conditions

Opioid Withdrawal, Opioid Use Disorder, Opioid Craving

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Study Overview

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Study Details

Study overview

Evaluate individual differences in the expression of opioid withdrawal symptoms in persons with opioid use disorder (OUD) while completing a clinically-indicated medication taper.

Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

Condition
Opioid Withdrawal
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins University Bayview Medical Campus, Baltimore, Maryland, United States, 21224

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18 years - 65 year old
  • * Opioid-positive urine sample
  • * Current opioid use disorder with evidence of physical dependence
  • * Interest in undergoing opioid taper
  • * Evidence of physical dependence on alcohol or benzodiazepines that requires medical intervention
  • * Being pregnant or breastfeeding
  • * Enrolled in methadone or buprenorphine maintenance treatment
  • * Clinically significant hypotension (\<90/60mmHg) or bradycardia (\<45bpm)
  • * History of myocardial infarction
  • * Subjects who are positive for hepatitis B surface antigen and/or hepatitis C antibody with liver function tests outside the normal range (persons with a positive hepatitis C antibody and normal liver functions tests are NOT excluded from the study)
  • * Significant mental health or physical disorder, or life circumstances, that is expected to interfere with study participation

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Johns Hopkins University,

Kelly E Dunn, Ph.D, M.B.A., PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2026-02-28