Evaluation of Smoked THC and CBD in Men and Women

Description

The purpose of this study is to determine the pharmacokinetics and pharmacodynamics of inhaled cannabis with varying amounts of delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD) and to evaluate detection of recently smoked THC in oral fluid.

Conditions

Drug Abuse, Intoxication by Drug, Impairment

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Study Overview

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Study Details

Study overview

The purpose of this study is to determine the pharmacokinetics and pharmacodynamics of inhaled cannabis with varying amounts of delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD) and to evaluate detection of recently smoked THC in oral fluid.

Evaluation of Smoked THC and CBD in Oral Fluid, Pharmacokinetics, and Subjective and Neurocognitive Effects in Men and Women

Evaluation of Smoked THC and CBD in Men and Women

Condition
Drug Abuse
Intervention / Treatment

-

Contacts and Locations

Los Angeles

University of California, Los Angeles, Los Angeles, California, United States, 90095

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male or non-pregnant and non-lactating females aged 21-55 years
  • * Report weekly-monthly use of cannabis (≤1 day per week) over the past month prior to screening,
  • * Not currently seeking treatment for their cannabis use
  • * Have a Body Mass Index from 18.5 - 34kg/m2.
  • * Able to perform all study procedures
  • * Must be using a contraceptive (hormonal or barrier methods)
  • * Meeting DSM-V criteria for moderate to severe Cannabis Use disorder (CUD) or any substance use disorder other than nicotine, caffeine
  • * Any other Axis I disorder
  • * Report using other illicit drugs in the prior 4 weeks, other than cannabis.
  • * Current use of any medications that may affect study outcomes
  • * If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process are not within the normal range and / or reveal any significant illness (e.g., hypertension) as judged by the study physician and to put the participant at greater risk of experiencing adverse events due to completion of study procedures.
  • * Pregnancy is exclusionary due to the possible effects of the study medication on fetal development.
  • * History of an allergic reaction or adverse reaction to cannabis is exclusionary.
  • * History of respiratory illness or current respiratory illness
  • * Currently enrolled in another research protocol
  • * Not using a contraceptive method (hormonal or barrier methods)
  • * The evaluating physician reviews all medical assessments along with medical history. Any disorders that might make cannabis administration hazardous are exclusionary.

Ages Eligible for Study

21 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, Los Angeles,

Ziva Cooper, PhD, PRINCIPAL_INVESTIGATOR, University of California, Los Angeles

Study Record Dates

2026-03-01