The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors

Description

The microbiome has the potential to serve as a robust biomarker of clinical response to immunotherapy. Additionally, microbial manipulation, through diet, exercise, prebiotics, probiotics, or microbially-derived metabolites, may prove to be beneficial in promoting anti-tumor immune responses. However, large prospective studies in humans with longitudinal sample collection and standardized methods are needed to understand how microbiota and their byproducts affect cancer therapies, particularly among patients undergoing identical therapy but experiencing different outcomes. The proposed observational study builds upon these hypotheses by proposing a large cohort design to further assess the associations between the gut microbiota (composition and function), host immune system, and ICI treatment efficacy across multiple cancer types.

Conditions

Non-Small-Cell Lung Carcinoma, Malignant Melanoma, Renal Cell Carcinoma, Triple-Negative Breast Cancer

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Study Overview

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Study Details

Study overview

The microbiome has the potential to serve as a robust biomarker of clinical response to immunotherapy. Additionally, microbial manipulation, through diet, exercise, prebiotics, probiotics, or microbially-derived metabolites, may prove to be beneficial in promoting anti-tumor immune responses. However, large prospective studies in humans with longitudinal sample collection and standardized methods are needed to understand how microbiota and their byproducts affect cancer therapies, particularly among patients undergoing identical therapy but experiencing different outcomes. The proposed observational study builds upon these hypotheses by proposing a large cohort design to further assess the associations between the gut microbiota (composition and function), host immune system, and ICI treatment efficacy across multiple cancer types.

The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors

The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors

Condition
Non-Small-Cell Lung Carcinoma
Intervention / Treatment

-

Contacts and Locations

Elizabethtown

Baptist Health Clinical Research, Elizabethtown, Kentucky, United States, 42701

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Men or women ≥18 years of age
  • 2. Screened negative for COVID-19 symptoms at time of consent, as per institutional policy and as applicable for the duration of the COVID-19 pandemic
  • 3. Diagnosed with stages I-IV primary NSCLC, MM, TNBC or RCC
  • 4. Plan to be treated at a partner cancer site with a checkpoint inhibitor (anti-PD-1, anti-PD-L1, or anti-CTLA-4) as a single agent or in combination with another checkpoint inhibitor or other treatment agent or modality (e.g., targeted therapy, chemotherapy, surgery, radiation, etc.) in accordance with FDA-labeled use of the agent
  • 5. Able to provide informed consent and answer study questionnaires in either English or Spanish
  • 6. Able to provide stool specimens for research purposes
  • 1. Mental incapacity
  • 2. Incarcerated individuals
  • 3. Pregnancy (by self-report of pregnancy status)
  • 4. Experiencing active brain metastasis/metastases
  • 5. Treatment with checkpoint inhibitor in off-label capacity or through a clinical/interventional trial
  • 6. Active participation in an immuno-oncology clinical/interventional trial or pharma-sponsored observational study

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VastBiome,

Study Record Dates

2028-09-14