Chronic Pain in Rheumatoid Arthritis

Description

The objective is to identify modifiable clinical factors and neurobiological pathways that lead to the development of chronic pain in patients with early rheumatoid arthritis. Participants will undergo quantitative sensory testing, a type of testing that involves assessing response to well-defined, quantifiable painful stimuli, at 0, 3, and 12 months. A subset of participants will also undergo magnetic resonance imaging at 0 and 12 months to assess neuroimaging markers that have previously been shown to be involved in chronic pain.

Conditions

Arthritis, Rheumatoid, Pain

Study Overview

Study Details

Study overview

The objective is to identify modifiable clinical factors and neurobiological pathways that lead to the development of chronic pain in patients with early rheumatoid arthritis. Participants will undergo quantitative sensory testing, a type of testing that involves assessing response to well-defined, quantifiable painful stimuli, at 0, 3, and 12 months. A subset of participants will also undergo magnetic resonance imaging at 0 and 12 months to assess neuroimaging markers that have previously been shown to be involved in chronic pain.

CNS Pain Mechanisms in Early Rheumatoid Arthritis: Implications for the Acute to Chronic Pain Transition

Chronic Pain in Rheumatoid Arthritis

Condition
Arthritis, Rheumatoid
Intervention / Treatment

-

Contacts and Locations

Denver

University of Colorado, Denver, Colorado, United States, 80045

Chicago

Northwestern University, Chicago, Illinois, United States, 60611

Baltimore

Johns Hopkins University, Baltimore, Maryland, United States, 21224

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48019

New York

Hospital for Special Surgery, New York, New York, United States, 10021

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Northwestern University,

    Yvonne C Lee, MD, MMSc, PRINCIPAL_INVESTIGATOR, Northwestern University

    Study Record Dates

    2026-04-12