COMPLETED

Improving Ventilatory Capacity in Those With Chronic High Level SCI

Conditions

Spinal Cord Injuries Pulmonary Function Test Buspirone Hydrochloride Oxygen Consumption

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to find out if taking the drug Buspar will increase breathing capacity in individuals with spinal cord injuries.

Official Title

Improving Ventilatory Capacity in Those With Chronic High Level SCI

Quick Facts

Study Start:2020-11-29

Study Completion:2024-11-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:COMPLETED

Study ID

NCT05041322

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Chronic high-level SCI (at least 24-months post injury) * Age 18 to 50 years. * Medically stable * Spinal Cord Injury ≥T3 * American Spinal Injury Association grade A or B or C. * Able to perform arm crank exercise.	* Cardiomyopathy * High blood pressure( \>140/90 mmHg or you are taking high blood pressure medication) * Significant irregular heartbeat * Heart disease * Chronic lung disease (COPD, bronchitis) * Current use of cardioactive or antidepressant drugs * Family history of significant irregular heart beat or sudden cardiac death * Orthostatic hypotension (symptomatic fall in blood pressure \>30 mmHg when upright) * Current grade 2 or greater pressure ulcers at relevant contact site * Neurological disease (stroke, peripheral neuropathy, myopathy) * Arm or shoulder conditions that limit ability to perform arm crank exercise * History of bleeding disorder, diabetes, kidney disease, cancer, other neurological disease * Recent weigh change (greater than 10 pounds) * Regular use of tobacco * Intrathecal baclofen pump, * Current use of cardioactive, antidepressant, other sedating agents * Suicidal ideation * Pregnant and/or breastfeeding women.

Inclusion Criteria

Exclusion Criteria

* Chronic high-level SCI (at least 24-months post injury)
* Age 18 to 50 years.
* Medically stable
* Spinal Cord Injury ≥T3
* American Spinal Injury Association grade A or B or C.
* Able to perform arm crank exercise.

* Cardiomyopathy
* High blood pressure( \>140/90 mmHg or you are taking high blood pressure medication)
* Significant irregular heartbeat
* Heart disease
* Chronic lung disease (COPD, bronchitis)
* Current use of cardioactive or antidepressant drugs
* Family history of significant irregular heart beat or sudden cardiac death
* Orthostatic hypotension (symptomatic fall in blood pressure \>30 mmHg when upright)
* Current grade 2 or greater pressure ulcers at relevant contact site
* Neurological disease (stroke, peripheral neuropathy, myopathy)
* Arm or shoulder conditions that limit ability to perform arm crank exercise
* History of bleeding disorder, diabetes, kidney disease, cancer, other neurological disease
* Recent weigh change (greater than 10 pounds)
* Regular use of tobacco
* Intrathecal baclofen pump,
* Current use of cardioactive, antidepressant, other sedating agents
* Suicidal ideation
* Pregnant and/or breastfeeding women.

Contacts and Locations

Study Locations (Sites)

Spaulding Hospital Cambridge

Cambridge, Massachusetts, 02138

United States

Collaborators and Investigators

Sponsor: Spaulding Rehabilitation Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-11-29

Study Completion Date2024-11-01

Study Record Updates

Study Start Date2020-11-29

Study Completion Date2024-11-01

Terms related to this study

Keywords Provided by Researchers

Pulmonary Function Test
Buspirone Hydrochloride
Oxygen Consumption

Additional Relevant MeSH Terms

Spinal Cord Injuries