Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)

Eligibility Criteria

• 1. Males and females 18-80 years of age
• 2. Fluency in English and a 6th grade or higher reading level
• 3. Meets the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for a current alcohol use disorder (subjects should have a primary alcohol use disorder \[AUD\] diagnosis, but may have concurrent occasional use of other substances)
• 4. Last alcohol use and at least one heavy drinking day within the past 30 days
• 5. Willingness to attend follow-up assessments at 13 weeks
• 6. Willingness to submit to Urine Toxicology screenings
• 1. Lifetime diagnosis of a psychotic disorder, not induced by drug use
• 2. Current treatment with opioids or benzodiazepines, which may affect new learning
• 3. Involvement in a legal case that may lead to incarceration during the study period
• 4. Residential plans that would interfere with participation
• 5. Medical illness that may significantly compromise cognition (e.g., Parkinson's, Alzheimer's, Huntington's chorea, moderate or greater TBI)
• 6. An uncorrected sensory impairment (hearing or sight) that would seriously interfere with cognitive training
• 7. Pre-morbid intelligence quotient (IQ) estimate below 70
• 8. Unstable housing or lack of commitment to staying within a geographic area that would make follow-up unlikely
• 9. Unwillingness to provide contact information of someone who can help study staff contact the subjects in the event that study staff are unable to maintain contact directly
• 10. Allergy to donepezil
• 11. Unstable cardiovascular disease or unstable medical condition-clinically determined by a physician
• 12. Imminent suicidal or homicidal risk
• 13. Pregnant or nursing women, positive pregnancy test, or inadequate birth control methods in women of childbearing potential