Autoimmune Basis for Postural Tachycardia Syndrome

Description

The purpose of this study is to test the hypothesis that an antibody-mediated autoimmune reaction will cause symptoms of autonomic dysfunction in some patients with postural tachycardia syndrome (POTS). The investigators further hypothesize that electrical stimulation of the vagus nerve will improve POTS symptoms, autoimmunity and inflammation.

Conditions

Postural Tachycardia Syndrome

Talk to us

Study Overview

On this page

Study Details

Study overview

The purpose of this study is to test the hypothesis that an antibody-mediated autoimmune reaction will cause symptoms of autonomic dysfunction in some patients with postural tachycardia syndrome (POTS). The investigators further hypothesize that electrical stimulation of the vagus nerve will improve POTS symptoms, autoimmunity and inflammation.

Autoimmune Basis for Postural Tachycardia Syndrome

Autoimmune Basis for Postural Tachycardia Syndrome

Condition
Postural Tachycardia Syndrome
Intervention / Treatment

-

Contacts and Locations

Oklahoma City

Oklahoma Clinical and Translational Science Institute, Oklahoma City, Oklahoma, United States, 73104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18-80 years old, female or male
  • * Either healthy control or individual with postural tachycardia syndrome (POTS) defined as heart rate increase \>30 bpm from supine within 10 min of standing, in the absence of orthostatic hypotension (\>20/10 mmHg fall in blood pressure), with chronic symptoms (\>6 months), and in the absence of other acute cause of orthostatic tachycardia
  • * Able and willing to provide informed consent
  • * Understand and be able to comply with the study procedures and restrictions
  • * Hypertension (\>150 mmHg systolic and \>100 mmHg diastolic) based on history or findings at screening
  • * Orthostatic hypotension (consistent drop in blood pressure \>20/10 mmHg with 10 min of standing)
  • * Cardiovascular disease, such as myocardial infarction within 6 months
  • * History or presence of significant immunological or hematological disorders
  • * History of vagotomy
  • * Currently pregnant women or women planning on becoming pregnant ≤ 3 months
  • * Inability to comply with the protocol
  • * Patients with active implants (such as a cardiac pacemaker, or a cochlear implant)

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Oklahoma,

Stavros Stavrakis, MD, STUDY_DIRECTOR, University of Oklahoma

Study Record Dates

2025-07-31