COMPLETED

Improving Age-Related Cognitive Decline With Exercise in Hypertensive Older Adults

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The investigator aims to assess the extent to which a brief exercise intervention improves systemic growth factor concentrations, reverses loss of systemic vascular networks and hypertension, and by extension, improves neurocognition. To test the investigator's hypothesis that increased cardiovascular fitness will correlate with improved vascular density, the investigator proposes the innovative use of retinal density scans.

Official Title

Improving Age-Related Cognitive Decline With Exercise in Hypertensive Older Adults: A Pilot Study to Investigate A Retinal Microvascular Biomarker and the Role of IGF

Quick Facts

Study Start:2021-10-01
Study Completion:2025-07-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT05043454

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * adults between 55-75 years of age
  2. * essential hypertension (as determined by referring physicians)
  3. * engages in less than 150 minutes of moderate intensity exercise/week (as determined by CHAMPS Questionnaire)
  4. * physically able to exercise
  5. * access to an upright cycle ergometer at home or via gym access
  6. * access to smart device (iOS or Android phone or tablet with ability to install and use Polar Beat and Polar FlowTM applications).
  1. * diagnosis of dementia
  2. * resting systolic blood pressure \<120, or \>180 mm Hg
  3. * disease or condition that would preclude exercise
  4. * untreated depression or anxiety disorders
  5. * severe respiratory disease
  6. * disease of the eye
  7. * refractive error \> 6 diopters or +6 diopters (as assessed by 1st retinal scan).

Contacts and Locations

Principal Investigator

Ronald Lazar, PhD
PRINCIPAL_INVESTIGATOR
University of Alabama at Birmingham

Study Locations (Sites)

University of Alabama at Birmingham
Birmingham, Alabama, 35233
United States

Collaborators and Investigators

Sponsor: University of Alabama at Birmingham

  • Ronald Lazar, PhD, PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-10-01
Study Completion Date2025-07-09

Study Record Updates

Study Start Date2021-10-01
Study Completion Date2025-07-09

Terms related to this study

Additional Relevant MeSH Terms

  • Hypertension